安徽医科大学学报
安徽醫科大學學報
안휘의과대학학보
ACTA UNIVERSITY MEDICINALIS ANHUI
2015年
6期
829-832
,共4页
PGI-BLDCL%预后%VEGF%CD10%Bcl-6
PGI-BLDCL%預後%VEGF%CD10%Bcl-6
PGI-BLDCL%예후%VEGF%CD10%Bcl-6
PGI-DLBCL%prognosis%VEGF%CD10%Bcl-6
目的：探讨原发于胃肠道的弥漫大 B 细胞淋巴瘤（PGI-DLBCL）的临床特征，CD10、Bcl-6和 VEGF 表达，分析其与预后的相关性。方法收集66例病理确诊原发 PGI-DLBCL 患者的临床资料，采用免疫组化法检测肿瘤组织CD10、Bcl-6及 VEGF 表达水平；应用 Hans 分型法、Kaplan-Meier 法、Log-rank 检验对患者进行分型，分析临床特征、CD10、Bcl-6及 VEGF 表达与无进展生存期（ PFS）相关性。结果66例患者，原发胃部36例（54.5%），原发肠道30例（45.5%）。生发中心型（GCB）39例（59.1%），非生发中心型（non-GCB 型）27例（40.9%）。肿瘤分期、国际预后指数（IPI）评分与 PFS 呈负相关性（P <0.05）。GCB 中位 PFS 为21.50个月，non-GCB 中位 PFS 12.00个月。Bcl-6阳性表达29例（43.9%），CD-10阳性表达23例（34.8%），VEGF 阳性表达29例（43.9%）；单因素分析结果提示 CD10、Bcl-6阳性表达与 PFS 呈正相关性（ P <0.05），而 VEGF 阳性表达与PFS 呈负相关性（P <0.05）；CD10、Bcl-6、VEGF 表达与临床特征之间无明显相关性。Cox 多因素预后分析提示治疗结果、Bcl-6及 VEGF 为影响生存时间的独立影响因素。结论PGI-DLBCL 是一类高侵袭性、高特异性的恶性肿瘤，Hans分型、肿瘤分期、IPI 评分、VEGF、CD10、Bcl-6表达均与其预后有相关性。
目的：探討原髮于胃腸道的瀰漫大 B 細胞淋巴瘤（PGI-DLBCL）的臨床特徵，CD10、Bcl-6和 VEGF 錶達，分析其與預後的相關性。方法收集66例病理確診原髮 PGI-DLBCL 患者的臨床資料，採用免疫組化法檢測腫瘤組織CD10、Bcl-6及 VEGF 錶達水平；應用 Hans 分型法、Kaplan-Meier 法、Log-rank 檢驗對患者進行分型，分析臨床特徵、CD10、Bcl-6及 VEGF 錶達與無進展生存期（ PFS）相關性。結果66例患者，原髮胃部36例（54.5%），原髮腸道30例（45.5%）。生髮中心型（GCB）39例（59.1%），非生髮中心型（non-GCB 型）27例（40.9%）。腫瘤分期、國際預後指數（IPI）評分與 PFS 呈負相關性（P <0.05）。GCB 中位 PFS 為21.50箇月，non-GCB 中位 PFS 12.00箇月。Bcl-6暘性錶達29例（43.9%），CD-10暘性錶達23例（34.8%），VEGF 暘性錶達29例（43.9%）；單因素分析結果提示 CD10、Bcl-6暘性錶達與 PFS 呈正相關性（ P <0.05），而 VEGF 暘性錶達與PFS 呈負相關性（P <0.05）；CD10、Bcl-6、VEGF 錶達與臨床特徵之間無明顯相關性。Cox 多因素預後分析提示治療結果、Bcl-6及 VEGF 為影響生存時間的獨立影響因素。結論PGI-DLBCL 是一類高侵襲性、高特異性的噁性腫瘤，Hans分型、腫瘤分期、IPI 評分、VEGF、CD10、Bcl-6錶達均與其預後有相關性。
목적：탐토원발우위장도적미만대 B 세포림파류（PGI-DLBCL）적림상특정，CD10、Bcl-6화 VEGF 표체，분석기여예후적상관성。방법수집66례병리학진원발 PGI-DLBCL 환자적림상자료，채용면역조화법검측종류조직CD10、Bcl-6급 VEGF 표체수평；응용 Hans 분형법、Kaplan-Meier 법、Log-rank 검험대환자진행분형，분석림상특정、CD10、Bcl-6급 VEGF 표체여무진전생존기（ PFS）상관성。결과66례환자，원발위부36례（54.5%），원발장도30례（45.5%）。생발중심형（GCB）39례（59.1%），비생발중심형（non-GCB 형）27례（40.9%）。종류분기、국제예후지수（IPI）평분여 PFS 정부상관성（P <0.05）。GCB 중위 PFS 위21.50개월，non-GCB 중위 PFS 12.00개월。Bcl-6양성표체29례（43.9%），CD-10양성표체23례（34.8%），VEGF 양성표체29례（43.9%）；단인소분석결과제시 CD10、Bcl-6양성표체여 PFS 정정상관성（ P <0.05），이 VEGF 양성표체여PFS 정부상관성（P <0.05）；CD10、Bcl-6、VEGF 표체여림상특정지간무명현상관성。Cox 다인소예후분석제시치료결과、Bcl-6급 VEGF 위영향생존시간적독립영향인소。결론PGI-DLBCL 시일류고침습성、고특이성적악성종류，Hans분형、종류분기、IPI 평분、VEGF、CD10、Bcl-6표체균여기예후유상관성。
Objective To investigate the correlation between the expression of CD10,Bcl-6,VEGF with clinical characteristics and the prognosis in the primary gastrointestinal diffuse large B-cell lymphoma. Methods The clini-cal characteristics data of 66 patients with PGI-DLBCL were determined the levels of CD10,Bcl-6 and VEGF by immunohisto-chemical staining. Analyzed their correlation via Kaplan-Meier method and Log-rand test. Results Among those 66 patients,there were 36 cases(54. 5% )of primary stomach,while other 30 cases(45. 5% )were primary intestinal. 39 cases were GCB and 27 cases were non-GCB. The tumor stage and IPI were inverse propor-tion with the prognosis. The median progression-free-survival of GCB was 21. 50 months while non-GCB was 12. 00 months. The positive expression rate of Bcl-6 was 43. 9%(29 / 66)while that of CD10 was 34. 8%(23 / 66)and there were 29 cases(43. 9% )with positive expression of VEGF. Log-rank test revealed there was a positive correc-tion between the positive impression of CD10,Bcl-6 and PFS. On the contrary,the relationship between the ex-pressions of VEGF and PFS was negative. The expressions of CD10,Bcl-6 and VEGF were not correlated with clini-cal features. Cox multivariable analysis showed that the curative effect,the expressions of Bcl-6 and VEGF were in-dependent prognostic factors. Conclusion PGI-DLBCL is a highly invasive and heterogeneous malignancy. The stage of disease,the Hans classification,the level of IPI,the expression of CD10,Bcl-6 and VEGF may play im-portant roles in predicting the curative effect and the prognosis of the disease.
