CAJ | 학술논문

目的：探讨不同核苷类抗病毒药物在乙肝肝硬化治疗中的疗效。方法我院2011年1月～2013年12月间收治的乙肝肝硬化患者93例，采用随机数字表法分为L组（给予拉米夫定）、A组（阿德福韦酯）和E组（恩替卡韦），比较三组治疗6、12个月后ALT水平及HBeAg阴转率。结果 E组治疗后12个月后HBeAg阴转率均高于L组和A组（P＜0.05），差异有统计学意义。结论乙肝肝硬化患者应用核苷类抗病毒药物治疗效果较好，其中恩替卡韦效果较拉米夫定和阿德福韦酯更好。
목적：탐토불동핵감류항병독약물재을간간경화치료중적료효。방법아원2011년1월～2013년12월간수치적을간간경화환자93례，채용수궤수자표법분위L조（급여랍미부정）、A조（아덕복위지）화E조（은체잡위），비교삼조치료6、12개월후ALT수평급HBeAg음전솔。결과 E조치료후12개월후HBeAg음전솔균고우L조화A조（P＜0.05），차이유통계학의의。결론을간간경화환자응용핵감류항병독약물치료효과교호，기중은체잡위효과교랍미부정화아덕복위지경호。
Objective To investigate the effect of different nucleoside antiviral drugs in the treatment of hepatitis B cirrhosis.Methods93 cases of patients with hepatitis B cirrhosis from 2011 January to 2013 December in our hospital, were randomly divided into L group (lamivudine), group A (Adefovir dipivoxil) and group E (entecavir), compared three groups of treatment 6,12 months after the ALT level and HBeAg negative conversion rate. ResultsAfter treatment in group E 12 months after the negative rate of HBeAg were significantly higher than those in L group and A group (P<0.05), the difference was statistically signiifcant.Conclusion The better therapeutic effect of nucleoside antiviral drugs used in hepatitis B cirrhosis patients, including entecavir effect better than lamivudine and adefovir dipivoxil.