医学影像学杂志
醫學影像學雜誌
의학영상학잡지
JOURNAL OF MEDICAL IMAGING
2015年
5期
892-896
,共5页
董津邑%朱海云%崔恒武%葛宇曦
董津邑%硃海雲%崔恆武%葛宇晞
동진읍%주해운%최항무%갈우희
正电子发射体层成像%射频消融%疗效%病理学
正電子髮射體層成像%射頻消融%療效%病理學
정전자발사체층성상%사빈소융%료효%병이학
Positron emission tomography%Radiofrequency ablation%Therapeutic effect%Pathology
目的：评价PET／CT在兔后肢VX2肉瘤射频消融（radiofrequency ablation ，RFA ）术后近期疗效中的价值。方法16只载瘤兔（共32个肿瘤）随机分为两组：RFA治疗组和对照组（不作任何治疗），每组8只，16个肿瘤。在动物肿瘤模型制作后20天左右行射频治疗，治疗前1～3天、治疗后1周和4周进行PET／CT检查并于四周检查后处死，行病理学检查和免疫组织化学检测。结果① RFA术前肿瘤最大标准摄取值（standardized uptake value ，SUVmax）为5．306±1．246，RFA术后1周、4周坏死区SUVmax 分别为2．169±0．681、1．987±0．611，外周炎性反应SUVmax 分别为2.681±0．353、2．331±0．461，均明显低于RFA治疗前（ P ＜0．05）；RFA术后1周、4周残余瘤组织SUVmax （5．606±1.254、5．338±1．300）均明显高于炎性反应（ P ＜0．05）；②16个病灶RFA治疗后，经病理证实残留灶12例（75％），完全失去活性病灶4例；术后1周和4周，PET／CT分别发现残留灶15例（94％）和13例（81％），PET／CT和病理结果之间差异均无统计学意义（ P ＞0．05）。结论 PET／CT 能够准确反应兔后肢 VX2肉瘤射频消融术后的病理学变化，是评价RFA治疗早期疗效的一种理想方法。
目的：評價PET／CT在兔後肢VX2肉瘤射頻消融（radiofrequency ablation ，RFA ）術後近期療效中的價值。方法16隻載瘤兔（共32箇腫瘤）隨機分為兩組：RFA治療組和對照組（不作任何治療），每組8隻，16箇腫瘤。在動物腫瘤模型製作後20天左右行射頻治療，治療前1～3天、治療後1週和4週進行PET／CT檢查併于四週檢查後處死，行病理學檢查和免疫組織化學檢測。結果① RFA術前腫瘤最大標準攝取值（standardized uptake value ，SUVmax）為5．306±1．246，RFA術後1週、4週壞死區SUVmax 分彆為2．169±0．681、1．987±0．611，外週炎性反應SUVmax 分彆為2.681±0．353、2．331±0．461，均明顯低于RFA治療前（ P ＜0．05）；RFA術後1週、4週殘餘瘤組織SUVmax （5．606±1.254、5．338±1．300）均明顯高于炎性反應（ P ＜0．05）；②16箇病竈RFA治療後，經病理證實殘留竈12例（75％），完全失去活性病竈4例；術後1週和4週，PET／CT分彆髮現殘留竈15例（94％）和13例（81％），PET／CT和病理結果之間差異均無統計學意義（ P ＞0．05）。結論 PET／CT 能夠準確反應兔後肢 VX2肉瘤射頻消融術後的病理學變化，是評價RFA治療早期療效的一種理想方法。
목적：평개PET／CT재토후지VX2육류사빈소융（radiofrequency ablation ，RFA ）술후근기료효중적개치。방법16지재류토（공32개종류）수궤분위량조：RFA치료조화대조조（불작임하치료），매조8지，16개종류。재동물종류모형제작후20천좌우행사빈치료，치료전1～3천、치료후1주화4주진행PET／CT검사병우사주검사후처사，행병이학검사화면역조직화학검측。결과① RFA술전종류최대표준섭취치（standardized uptake value ，SUVmax）위5．306±1．246，RFA술후1주、4주배사구SUVmax 분별위2．169±0．681、1．987±0．611，외주염성반응SUVmax 분별위2.681±0．353、2．331±0．461，균명현저우RFA치료전（ P ＜0．05）；RFA술후1주、4주잔여류조직SUVmax （5．606±1.254、5．338±1．300）균명현고우염성반응（ P ＜0．05）；②16개병조RFA치료후，경병리증실잔류조12례（75％），완전실거활성병조4례；술후1주화4주，PET／CT분별발현잔류조15례（94％）화13례（81％），PET／CT화병리결과지간차이균무통계학의의（ P ＞0．05）。결론 PET／CT 능구준학반응토후지 VX2육류사빈소융술후적병이학변화，시평개RFA치료조기료효적일충이상방법。
Objective To evaluate the short‐term effect of radiofrequency ablation (RFA) for VX2 tumors in hind limbs of rabbits by PET/CT .Methods Sixteen rabbits with hind limbs VX2 tumors (thirty‐two lesions) were randomly divided into two groups:RFA group and control group ( underwent no any therapy) .Each group had 8 rabbits (16 lesions) .The rabbits were performed RFA at about twenty days after VX2 implantation .All rabbits were imaged with 18 F‐FDG PET/CT at one to three days before RFA and one week and four weeks after RFA .The rabbits in each group were sacrificed af‐ter imaging examination for pathology and immunohistochemistry studies .Results ① Before RFA ,the standardized up‐take value (SUV) of tumor tissue was 5 .306 ± 1 .246 .After treatment ,the SUVs of necrosis tissue were 2 .169 ± 0 .681 and 1 .987 ± 0 .611 respectively at one week and four weeks after RFA .The SUVs of inflammatory reaction were 2 .681 ± 0.353 and 2 .331 ± 0 .461 respectively .The SUVs decreased significantly after RFA ( P <0 .05) .The SUVs of residual tumor tissue (5 .606 ± 1 .254 ,5 .338 ± 1 .300) were higher than inflammatory reaction at one week and four weeks after RFA ;② There were 12 active lesions (75% ) and 4 completely lost active lesions confirmed by pathology after RFA . PET/CT detected 15 active lesions (94% ) and 13 active lesions (81% ) respectively at one week and four weeks after RFA .The results had no significant difference between PET/CT and pathology ( P>0 .05) .Conclusion 18 F‐FDG PET/CT can response pathological changes of rabbit VX2 tumors after RFA accurately .It is an excellent imaging modality of e‐valuating early therapeutic efficacy of radiofrequency ablation .
