CAJ | 학술논문

目的：探讨前列地尔治疗次大面积肺栓塞合并肺动脉高压临床效果。方法选取我院近期收治次大面积肺栓塞合并肺动脉高压患者80例，采用随机抽样方法分为对照组（40例）和观察组（40例），分别采用常规抗凝治疗和在此基础上加用前列地尔泵入治疗；比较两组患者治疗前后肺动脉压水平及并发症发生情况。结果观察组患者治疗后2周和12周肺动脉压水平低于对照组、治疗前（P＜0.05）；两组患者并发症发生率比较差异无统计学意义（P＞0.05）。结论前列地尔治疗次大面积肺栓塞合并肺动脉高压可有效降低肺动脉压，且未增加并发症发生风险。
목적：탐토전렬지이치료차대면적폐전새합병폐동맥고압림상효과。방법선취아원근기수치차대면적폐전새합병폐동맥고압환자80례，채용수궤추양방법분위대조조（40례）화관찰조（40례），분별채용상규항응치료화재차기출상가용전렬지이빙입치료；비교량조환자치료전후폐동맥압수평급병발증발생정황。결과관찰조환자치료후2주화12주폐동맥압수평저우대조조、치료전（P＜0.05）；량조환자병발증발생솔비교차이무통계학의의（P＞0.05）。결론전렬지이치료차대면적폐전새합병폐동맥고압가유효강저폐동맥압，차미증가병발증발생풍험。
Objective To investigate clinical effects of alprostadil in treatment of patients with submassive pulmonary embolism complicated with pulmonary hypertension.Methods80 patients with submassive pulmonary embolism complicated with pulmonary hypertension were chosen and randomly divided into 2 groups including control group (40 patients) with conventional anticoagulant therapy and observation group (40 patients) with alprostadil treatment on the basis of control group; and the before and after treatment levels of pulmonary arterial pressure and complications occurrence of both groups were compared.ResultsThe treatment levels of pulmonary arterial pressure in 2 weeks and 12 weeks of observation group was signiifcant better than control group (P<0.05). There was no signiifcant difference in complication incidence between 2 groups (P<0.05).Conclusion Alprostadil in treatment of patients with submassive pulmonary embolism complicated with pulmonary hypertension can efifciently reduce pulmonary artery pressureand did not increase the risk of complications.