广西科学
廣西科學
엄서과학
GUANGXI SCIENCES
2015年
2期
148-152
,共5页
陈敬民%袁志林%吴超伟%李开双
陳敬民%袁誌林%吳超偉%李開雙
진경민%원지림%오초위%리개쌍
榕树须%凝血酶时间%纤维蛋白原时间%脑血栓
榕樹鬚%凝血酶時間%纖維蛋白原時間%腦血栓
용수수%응혈매시간%섬유단백원시간%뇌혈전
Ficus microcarpa%aerial roots%thrombin time%fibrinogen time%cerebral thrombosis
【目的】探讨榕树须不同提取物的抗脑血栓作用,并评价其对凝血功能的影响。【方法】采用小鼠脑偏瘫、电刺激致大鼠血栓模型观察提取物对小鼠脑血栓的保护率、大鼠血栓形成时间的影响；采用肾上腺素加冰浴致小鼠血瘀模型观察其对凝血酶时间及纤维蛋白原时间的影响。【结果】榕树须95%、80%醇提物的不同提取部位能提高小鼠脑偏瘫恢复率(20%~60%)；乙酸乙酯及正丁醇部位对电刺激引起的脑血栓有较好保护作用(P <0.01,P<0.001)；乙酸乙酯部位及正丁醇部位均能延长寒凝血瘀小鼠的凝血酶时间(P <0.05,P <0.001)；正丁醇部位能延长寒凝血瘀小鼠的纤维蛋白原时间(P<0.05)。【结论】榕树须80%醇提物的正丁醇部位具有较好的抗脑血栓及改善血瘀小鼠凝血功能的作用。
【目的】探討榕樹鬚不同提取物的抗腦血栓作用,併評價其對凝血功能的影響。【方法】採用小鼠腦偏癱、電刺激緻大鼠血栓模型觀察提取物對小鼠腦血栓的保護率、大鼠血栓形成時間的影響；採用腎上腺素加冰浴緻小鼠血瘀模型觀察其對凝血酶時間及纖維蛋白原時間的影響。【結果】榕樹鬚95%、80%醇提物的不同提取部位能提高小鼠腦偏癱恢複率(20%~60%)；乙痠乙酯及正丁醇部位對電刺激引起的腦血栓有較好保護作用(P <0.01,P<0.001)；乙痠乙酯部位及正丁醇部位均能延長寒凝血瘀小鼠的凝血酶時間(P <0.05,P <0.001)；正丁醇部位能延長寒凝血瘀小鼠的纖維蛋白原時間(P<0.05)。【結論】榕樹鬚80%醇提物的正丁醇部位具有較好的抗腦血栓及改善血瘀小鼠凝血功能的作用。
【목적】탐토용수수불동제취물적항뇌혈전작용,병평개기대응혈공능적영향。【방법】채용소서뇌편탄、전자격치대서혈전모형관찰제취물대소서뇌혈전적보호솔、대서혈전형성시간적영향；채용신상선소가빙욕치소서혈어모형관찰기대응혈매시간급섬유단백원시간적영향。【결과】용수수95%、80%순제물적불동제취부위능제고소서뇌편탄회복솔(20%~60%)；을산을지급정정순부위대전자격인기적뇌혈전유교호보호작용(P <0.01,P<0.001)；을산을지부위급정정순부위균능연장한응혈어소서적응혈매시간(P <0.05,P <0.001)；정정순부위능연장한응혈어소서적섬유단백원시간(P<0.05)。【결론】용수수80%순제물적정정순부위구유교호적항뇌혈전급개선혈어소서응혈공능적작용。
Objective]This study observed the effects of different extract substances from the aerial roots of Ficus microcarpa on coagulation,as well as the effect on cerebral thrombosis.[Methods]The mice model of cerebral thrombosis was induced by collagen protein and the rat thrombotic model was induced by electric stimulation,which were used to examine the effects of extract substances on the protective rate of mice cerebral thrombosis and rat thrombotic for-mation,respectively.The mice model of blood stasis was established by combined application of epinephrine with ice bath,which was used to observe the influences of the compounds on thrombin time and fibrinogen time.[Results]Different extract substances from 95% ASARFM (alcohol-soluble substance from the aerial roots of Ficus microcarpa )or 80% ASARFM could increase the recovery rate of cerebral thrombosis in mice (20%~60%).Both acetidine-soluble extract substance and n-butanol-soluble substance had better protective effect on the model of cerebral thrombosis by electric stimulation (P<0·01 and P <0·001),and could delay thrombin time of the mice with cold and stasis (P <0.05 and P <0.001 );N-butanol-soluble substance could delay fibrinogen time of the mice with cold and stasis (P <0.05).[Conclusion]N-butanol-soluble substance extracted from 80% ASARFM had better protective effect on the model of cerebral thrombosis and could improve the coagulation of mice.
