CAJ | 학술논문

目的：探讨 N －乙酰化转移酶2（NAT2）基因多态性与抗结核药物致肝损伤相关实验室指标的相关性。方法应用焦磷酸测序法检测抗结核治疗3个月内出现肝损伤患者41例和未出现肝损伤患者88例的 NAT2基因多态性，并对所有患者肝功能检测指标进行分析。结果抗结核治疗后，不同 NAT2乙酰基因型结核病病例的6项肝功能指标较治疗前均有升高（P 均＜0．01）。抗结核治疗后，不同基因型的 ALT 检测值之间存在差异（P ＜0．05），其中快乙酰型的 ALT 水平明显低于慢乙酰型（P ＜0．05）；但其他5项肝功能指标在不同基因型间的差异均无统计学意义（P ＞0．05）。结论 NAT2基因多态性与患者治疗后 ALT 水平升高存在一定相关性，应重视该指标的变化。
목적：탐토 N －을선화전이매2（NAT2）기인다태성여항결핵약물치간손상상관실험실지표적상관성。방법응용초린산측서법검측항결핵치료3개월내출현간손상환자41례화미출현간손상환자88례적 NAT2기인다태성，병대소유환자간공능검측지표진행분석。결과항결핵치료후，불동 NAT2을선기인형결핵병병례적6항간공능지표교치료전균유승고（P 균＜0．01）。항결핵치료후，불동기인형적 ALT 검측치지간존재차이（P ＜0．05），기중쾌을선형적 ALT 수평명현저우만을선형（P ＜0．05）；단기타5항간공능지표재불동기인형간적차이균무통계학의의（P ＞0．05）。결론 NAT2기인다태성여환자치료후 ALT 수평승고존재일정상관성，응중시해지표적변화。
Objective To know the relationship between NAT2 genetic polymorphisms and biomarkers related to anti -tuberculosis drug -induced liver injury (ATLI).Methods A total of 41 pulmonary tuberculosis patients with ATLI who received treatment within three months and 88 patients without ATLI were enrolled.The NAT2 genotypes were analyzed by pyrosequencing,and the biomarkers of liver function were analyzed.Results After anti -tuberculosis treatment,six biomarkers of liver function of pulmonary tuberculosis patients with different NAT2 genotypes were significantly higher than those before treatment(P <0.01 ).And there were significant differences in ALT level between different genotypes(P <0.05),the ALT levels of the fast acetylation genotype were significantly lower than that of the slow acetylation genotype(P<0.05 ),but no significant differences were observed in the other 5 biomarkers of liver function between different genotypes(P >0.05).Conclusion There is a certain relationship between NAT2 genetic polymorphisms and the elevated ALT levels among pulmonary tuberculosis patients after treatment.