CAJ | 학술논문

目的：研究脂肪酸代谢变化与原发性高血压发生的关系。方法采用气相色谱法测定原发性高血压患者血清脂肪酸谱，分析原发性高血压患者血清脂肪酸谱和血压的相关性。结果原发性高血压患者脂肪酸含量分布有性别差异，男性 C20：5n －3[（4．68±1．36）％ vs （4．01±1．22）％]、C22：6n －3[（2．03±0．73）％ vs （1．62±0．54）％]、总 n －3多不饱和脂肪酸[（8．13±1．87）％ vs （7．08±1．43）％]、C20：4n －6[（6．13±1．66）％ vs （5．31±1．25）％]和 n －3／n －6比[（0．24±0．07）％ vs （0．20±0．05）％]高于女性，而男性 C18：3n－6[（0．45±0．17）％ vs （0．58±0．29）％]和 C20：3n －6[（1．39±0．29）％ vs （1．60±0．49）％]低于女性。相关性分析显示原发性高血压患者血清 C18：3n －3与收缩压（r ＝－0．23，P ＜0．05）和脉压（r ＝－0．23，P ＜0．05）呈负相关，收缩压和脉压随着血清 C18：3n －3含量的增加而下降（P趋势＝0．01）。结论原发性高血压患者不同性别间血清脂肪酸谱有差异；血清 C18：3n －3对原发性高血压患者的血压可能具有保护作用。
목적：연구지방산대사변화여원발성고혈압발생적관계。방법채용기상색보법측정원발성고혈압환자혈청지방산보，분석원발성고혈압환자혈청지방산보화혈압적상관성。결과원발성고혈압환자지방산함량분포유성별차이，남성 C20：5n －3[（4．68±1．36）％ vs （4．01±1．22）％]、C22：6n －3[（2．03±0．73）％ vs （1．62±0．54）％]、총 n －3다불포화지방산[（8．13±1．87）％ vs （7．08±1．43）％]、C20：4n －6[（6．13±1．66）％ vs （5．31±1．25）％]화 n －3／n －6비[（0．24±0．07）％ vs （0．20±0．05）％]고우녀성，이남성 C18：3n－6[（0．45±0．17）％ vs （0．58±0．29）％]화 C20：3n －6[（1．39±0．29）％ vs （1．60±0．49）％]저우녀성。상관성분석현시원발성고혈압환자혈청 C18：3n －3여수축압（r ＝－0．23，P ＜0．05）화맥압（r ＝－0．23，P ＜0．05）정부상관，수축압화맥압수착혈청 C18：3n －3함량적증가이하강（P추세＝0．01）。결론원발성고혈압환자불동성별간혈청지방산보유차이；혈청 C18：3n －3대원발성고혈압환자적혈압가능구유보호작용。
Objective To explore the relationship between serum fatty acids and blood pressure among hypertension patients.Methods A total of 93 primary hypertension patients were recruited.Serum fatty acids were determined with capillary gas chromatography.Results There was a statistically significant difference in serum fatty acids composition between male and female patients.Serum compositions of C20:5n -3(4.68% ±1 .36% vs.4.01 % ±1 .22%),C22:6n -3(2.03% ±0.73% vs.1 .62% ±0.54%),total n -3 polyunsaturated fatty acids(8.1 3% ±1 .87% vs.7.08% ± 1 .43%),C20:4n -6(6.1 3% ±1 .66% vs.5.31 % ±1 .25%)and n -3 to n -6 ratio (0.24% ±0.07% vs.0.20% ± 0.05%)among males were significantly higher than that of females,while C1 8:3n -6 (0.45% ±0.1 7% vs.0.58% ± 0.29%)and C20:3n -6 (1 .39% ±0.29% vs.1 .60% ±0.49%)compositions in serum were significantly lower in males.Serum composition of C1 8:3n -3 was significantly negatively correlated to systolic blood pressure (r =-0.23,P =0.03)and pulse pressure (r =-0.23,P =0.03).Conclusion Increased serum composition of C1 8:3n -3 is associated with decreased systolic and pulse pressure.