中国真菌学杂志
中國真菌學雜誌
중국진균학잡지
CHINESE JOURNAL OF MYCOLOGY
2015年
2期
115-117
,共3页
蔡晴%戴鹤骏%高志琴%杨虹%任香玉%张敏%杨连娟
蔡晴%戴鶴駿%高誌琴%楊虹%任香玉%張敏%楊連娟
채청%대학준%고지금%양홍%임향옥%장민%양련연
硝酸舍他康唑%念珠菌性皮炎%抗真菌药物%婴幼儿
硝痠捨他康唑%唸珠菌性皮炎%抗真菌藥物%嬰幼兒
초산사타강서%념주균성피염%항진균약물%영유인
Sertaconazole%dermatitis candidiasis%antifungal%infant
目的:观察硝酸舍他康唑乳膏治疗婴幼儿念珠菌性皮炎的临床疗效和安全性。方法入选26例0~3岁念珠菌性皮炎的患儿,均经临床表现及真菌学检查确诊,外用硝酸舍他康唑乳膏2次/ d,连续7~14 d,观察其临床疗效及治疗前后真菌学变化。结果26例患儿治疗7 d 临床评分均值由6分下降至1.35分,下降幅度超过75%。治疗7 d 临床痊愈率为57.69%,有效率为92.3%,真菌学阴转率为88.46%;14 d 临床痊愈率为92.3%,真菌学阴转率为92.3%。停药后第14天随访痊愈患儿91.67%未见复发。仅1例患儿出现不良反应。结论硝酸舍他康唑乳膏治疗婴幼儿皮肤念珠菌病安全、有效,不良反应少,值得临床推广。
目的:觀察硝痠捨他康唑乳膏治療嬰幼兒唸珠菌性皮炎的臨床療效和安全性。方法入選26例0~3歲唸珠菌性皮炎的患兒,均經臨床錶現及真菌學檢查確診,外用硝痠捨他康唑乳膏2次/ d,連續7~14 d,觀察其臨床療效及治療前後真菌學變化。結果26例患兒治療7 d 臨床評分均值由6分下降至1.35分,下降幅度超過75%。治療7 d 臨床痊愈率為57.69%,有效率為92.3%,真菌學陰轉率為88.46%;14 d 臨床痊愈率為92.3%,真菌學陰轉率為92.3%。停藥後第14天隨訪痊愈患兒91.67%未見複髮。僅1例患兒齣現不良反應。結論硝痠捨他康唑乳膏治療嬰幼兒皮膚唸珠菌病安全、有效,不良反應少,值得臨床推廣。
목적:관찰초산사타강서유고치료영유인념주균성피염적림상료효화안전성。방법입선26례0~3세념주균성피염적환인,균경림상표현급진균학검사학진,외용초산사타강서유고2차/ d,련속7~14 d,관찰기림상료효급치료전후진균학변화。결과26례환인치료7 d 림상평분균치유6분하강지1.35분,하강폭도초과75%。치료7 d 림상전유솔위57.69%,유효솔위92.3%,진균학음전솔위88.46%;14 d 림상전유솔위92.3%,진균학음전솔위92.3%。정약후제14천수방전유환인91.67%미견복발。부1례환인출현불량반응。결론초산사타강서유고치료영유인피부념주균병안전、유효,불량반응소,치득림상추엄。
Objective To investigate the clinical efficacy and safety of sertaconazole cream on infant suffering from dermatitis candidiasis.Method Twenty?six patients with clinical and mycological diagnosis of dermatitis candidiasis were enrolled. Patients were treated with twice daily applications of sertaconazole cream for 14 days and were followed?up for 2 further weeks.Results Twen?ty?two Candida albicans and four non?Candida albicans were isolated in twenty?six infants.The treatment evaluation after 7 days treat?ment showed that more than 75% of average signs decreased from 6 to 1.35.There was a total clinical cure in 57.69%,improvement in 92.3% and mycological cure in 88.46% after 7 days treatment.At the time of 14 days follow?up,there was a total clinical and myco?logical cure in 92.3%.91.67% cure infants had not recurred at the end of the follow?up period.There was side effect in only one pa?tient.Conclusions Based on its safety and effectiveness,sertaconazole cream may be considered a new alternative for infant dermati?tis candidiasis treatment.