中国真菌学杂志
中國真菌學雜誌
중국진균학잡지
CHINESE JOURNAL OF MYCOLOGY
2015年
2期
100-103
,共4页
曹伟胜%陈少南%韦方铨%陈伟华%张凤霞
曹偉勝%陳少南%韋方銓%陳偉華%張鳳霞
조위성%진소남%위방전%진위화%장봉하
包皮龟头炎%真菌%念珠菌%药敏试验
包皮龜頭炎%真菌%唸珠菌%藥敏試驗
포피구두염%진균%념주균%약민시험
balanoposthitis%fungi%Candida%susceptibility test
目的：了解本地区包皮龟头炎患者中真菌感染情况及对抗生素的敏感性。方法分别采用显微镜、科玛嘉念珠菌显色培养基、法国梅里埃公司的 ATB ID32C 酵母菌鉴定卡和 Rosco 纸片扩散法对包皮龟头分泌物进行直接镜检、念珠菌培养、菌种鉴定及药敏试验。结果458例患者中153例直接镜检阳性，培养分离出念珠菌共157株，念珠菌培养阳性率为33．4％（153／458），其中白念珠菌116株，占73．9％（116／157），非白念珠菌41株，占26．1％（41／157）；120例对照组中有17例培养出念珠菌，阳性率为14．2％（17／120），其中白念珠菌6株，占35．3％（6／17），非白念珠菌11株，占64．7％（11／17）。包皮龟头炎患者组念珠菌的培养阳性率和白念珠菌的比例均高于健康对照组，差异有统计学意义（χ2＝16．95，χ2＝10．72，P 均＜0．05）。157株致病菌株对制霉菌素和酮康唑的敏感率均＞90％，分别为97．5％和93．0％，对氟康唑敏感率为79．6％，而对特比萘芬敏感性最低，为33．8％。结论念珠菌感染是本地区包皮龟头炎发病的重要因素，感染的致病菌种以白念珠菌为主，分离的致病性念珠菌对多烯类药物敏感率较高，对唑类抗真菌药有不同程度的交叉耐药，不同菌型其药敏谱存在差异。
目的：瞭解本地區包皮龜頭炎患者中真菌感染情況及對抗生素的敏感性。方法分彆採用顯微鏡、科瑪嘉唸珠菌顯色培養基、法國梅裏埃公司的 ATB ID32C 酵母菌鑒定卡和 Rosco 紙片擴散法對包皮龜頭分泌物進行直接鏡檢、唸珠菌培養、菌種鑒定及藥敏試驗。結果458例患者中153例直接鏡檢暘性，培養分離齣唸珠菌共157株，唸珠菌培養暘性率為33．4％（153／458），其中白唸珠菌116株，佔73．9％（116／157），非白唸珠菌41株，佔26．1％（41／157）；120例對照組中有17例培養齣唸珠菌，暘性率為14．2％（17／120），其中白唸珠菌6株，佔35．3％（6／17），非白唸珠菌11株，佔64．7％（11／17）。包皮龜頭炎患者組唸珠菌的培養暘性率和白唸珠菌的比例均高于健康對照組，差異有統計學意義（χ2＝16．95，χ2＝10．72，P 均＜0．05）。157株緻病菌株對製黴菌素和酮康唑的敏感率均＞90％，分彆為97．5％和93．0％，對氟康唑敏感率為79．6％，而對特比萘芬敏感性最低，為33．8％。結論唸珠菌感染是本地區包皮龜頭炎髮病的重要因素，感染的緻病菌種以白唸珠菌為主，分離的緻病性唸珠菌對多烯類藥物敏感率較高，對唑類抗真菌藥有不同程度的交扠耐藥，不同菌型其藥敏譜存在差異。
목적：료해본지구포피구두염환자중진균감염정황급대항생소적민감성。방법분별채용현미경、과마가념주균현색배양기、법국매리애공사적 ATB ID32C 효모균감정잡화 Rosco 지편확산법대포피구두분비물진행직접경검、념주균배양、균충감정급약민시험。결과458례환자중153례직접경검양성，배양분리출념주균공157주，념주균배양양성솔위33．4％（153／458），기중백념주균116주，점73．9％（116／157），비백념주균41주，점26．1％（41／157）；120례대조조중유17례배양출념주균，양성솔위14．2％（17／120），기중백념주균6주，점35．3％（6／17），비백념주균11주，점64．7％（11／17）。포피구두염환자조념주균적배양양성솔화백념주균적비례균고우건강대조조，차이유통계학의의（χ2＝16．95，χ2＝10．72，P 균＜0．05）。157주치병균주대제매균소화동강서적민감솔균＞90％，분별위97．5％화93．0％，대불강서민감솔위79．6％，이대특비내분민감성최저，위33．8％。결론념주균감염시본지구포피구두염발병적중요인소，감염적치병균충이백념주균위주，분리적치병성념주균대다희류약물민감솔교고，대서류항진균약유불동정도적교차내약，불동균형기약민보존재차이。
Objective To investigate the infection and antibiotic susceptibility of fungi in the patients with balanoposthitis in Zhaoqing area.Methods Microscopy,CHROM agar candida,ATB ID32C of France Bio?Merieux Company and Rosco Disk diffusion method were applied to examine and culture and identify candida strains and for yeast susceptibility testing.Results 153 cases were positive fungal microscopy examination in 458 patients.There were 157 strains candida by culture and identify and the positive detec?tion rate was 33.4%.116 of 157 isolates (73.9%) were albicans,41 of 157 isolates (26.1%) were non?C.albicans.17 cases were cul?tured positive for candida in healthy control group and the positive detection rate was 14.2%.6 of 17 isolates (35.3%) were albicans, 11 of 17 isolates (64.7%) were non?C.albicans.The detection rate of candida culture and the constituent rate of albicans in patient group were higher than those in healthy control group,the difference has statistical significance ( χ 2 = 16.95, χ 2 = 10.72,P<0.05). The susceptibility rate of isolated pathogenic strain in nystatin and ketoconazole were all more than 90%,were 97.5% and 93.0%.The rate in fluconazole was 79.6%,while the lowest susceptibility rate was terbinafine (33.8%).Conclusion Candida infection is the most important pathogenetic factor for balanoposthitis and the main species of pathogenetic yeasts is albicans in Zhaoqing area.Patho?genic candida have a higher drug susceptibility rate to polyene drugs and have different degree of cross resistance to azole drugs.There are differences among the antibiotic sensitivity spectrums of various candida.
