CAJ | 학술논문

目的：探讨连续性血液净化在重症脓毒血症患者治疗中的应用价值。方法选取2012年1月至2013年12月收治的重症脓毒血症患者58例，随机分为观察组与对照组，各29例。对照组给予常规对症治疗；观察组在对照组治疗基础上加用连续性血液净化治疗，将两组患者治疗7 d 后的疗效进行对比。结果治疗后观察组患者血清肌酐、尿素氮、钠、氯、钾水平均优于对照组，白细胞介素－6、肿瘤坏死因子水平低于对照组，血压、呼吸频率、心率监测值优于对照组，死亡率低于对照组，差异均具有统计学意义（P ＜0．05）。结论将连续性血液净化方法治疗重症脓毒血症患者能够有效降低炎症细胞因子释放，纠正电解质紊乱，促进器官功能恢复，降低患者病死率。
목적：탐토련속성혈액정화재중증농독혈증환자치료중적응용개치。방법선취2012년1월지2013년12월수치적중증농독혈증환자58례，수궤분위관찰조여대조조，각29례。대조조급여상규대증치료；관찰조재대조조치료기출상가용련속성혈액정화치료，장량조환자치료7 d 후적료효진행대비。결과치료후관찰조환자혈청기항、뇨소담、납、록、갑수평균우우대조조，백세포개소－6、종류배사인자수평저우대조조，혈압、호흡빈솔、심솔감측치우우대조조，사망솔저우대조조，차이균구유통계학의의（P ＜0．05）。결론장련속성혈액정화방법치료중증농독혈증환자능구유효강저염증세포인자석방，규정전해질문란，촉진기관공능회복，강저환자병사솔。
Objective To investigate the application value of continuous blood purification in the treatment of patients with severe sepsis.Methods 58 patients with severe sepsis from January of 2012 to December of 2013 were selected and randomly divided into observation group and control group,29 cases in each.The control group was given conventional treatment,and ob-servation group was given continuous blood purification treatment in addition.The curative effect on the 7th day after treatment were compared between two groups.Results The levels of serum urea nitrogen,creatinine,sodium,chloride,potassium in ob-servation group were superior to control group,and the levels of interleukin 6 and tumor necrosis factor were lower than the con-trol group.Blood pressure,breathing rate,heart rate monitoring value in observation group were better,mortality rate was lower than the control group,the differences were statistically significant (P <0.05).Conclusion In the treatment of patients with severe sepsis,continuous blood purification method could effectively reduce the release of inflammatory cytokine,correct electro-lyte disorder,promote the recovery of organ function,reduce mortality.