CAJ | 학술논문

目的：研究食管鳞状细胞癌（esophageal squamous cell carcinoma，ESCC）组织中缺氧诱导因子（hypoxia inducible factor －1α，HIF －1α）、血管内皮生长因子－C （vascular endothelial growth factor，VEGF －C）的表达及其与临床病理特征的关系。方法采用免疫组织化学（SP）法检测116例 ESCC 及20例癌旁组织组织中 HIF －1α、VEGF －C 蛋白的表达，并分析其与临床病理特征的关系。结果HIF －1α与 VEGF －C 在 ESCC 组织中的阳性表达率均高于癌旁组织（P ＜0.05）。HIF －1α蛋白的阳性表达与 T 分期相关（P ＜0.05）。VEGF －C 与分化程度、淋巴结转移相关（P ＜0.05）。HIF －1α与 VEGF －C 蛋白表达之间存在着显著的正相关关系（r ＝0.331，P ＝0.000）。结论HIF －1α、VEGF －C 蛋白在 ESCC 组织中高表达，可能在 ESCC 发生发展中有重要作用。VEGF －C 表达与淋巴结转移有关，可作为预测 ESCC 预后的重要指标。
목적：연구식관린상세포암（esophageal squamous cell carcinoma，ESCC）조직중결양유도인자（hypoxia inducible factor －1α，HIF －1α）、혈관내피생장인자－C （vascular endothelial growth factor，VEGF －C）적표체급기여림상병리특정적관계。방법채용면역조직화학（SP）법검측116례 ESCC 급20례암방조직조직중 HIF －1α、VEGF －C 단백적표체，병분석기여림상병리특정적관계。결과HIF －1α여 VEGF －C 재 ESCC 조직중적양성표체솔균고우암방조직（P ＜0.05）。HIF －1α단백적양성표체여 T 분기상관（P ＜0.05）。VEGF －C 여분화정도、림파결전이상관（P ＜0.05）。HIF －1α여 VEGF －C 단백표체지간존재착현저적정상관관계（r ＝0.331，P ＝0.000）。결론HIF －1α、VEGF －C 단백재 ESCC 조직중고표체，가능재 ESCC 발생발전중유중요작용。VEGF －C 표체여림파결전이유관，가작위예측 ESCC 예후적중요지표。
Objective To investigate the expression of hypoxia -inducible factor -1α(HIF -1α)and vascular endothelial growth factor -c(VEGF -C)in esophageal squamous cell carcinoma(ESCC)tissues and the correlation with the clinicopatholog-ical features.Methods The expression of HIF -1αand VEGF -C in 106 cases of esophageal squamous cell carcinoma tissues and 20 cases of adjacent esophageal mucosa were detected by immunohistochemical staining,and the correlation with clinicopath-ological features were analyzed.Results The positive expression rates of HIF -1αand VEGF -C were higher than adjacent e-sophageal mucosa(P <0.05 ).The expression of HIF -1αwas correlated with T stage (P <0.05 ),and the expression of VEGF -C was correlated with differentiation and lymph metastasis (P <0.05).There was a significantly positive correlation be-tween HIF -1αand VEGF -C protein expression(r =0.331,P =0.000).Conclusion The expression levels of HIF -1αand VEGF -C were higher,and they may play important roles in the development and progression of ESCC.The expression of VEGF -C was correlated with lymph metastasis,and it may be used as an important index to predict the prognosis of ESCC.