江西医药
江西醫藥
강서의약
JIANGXI MEDICAL JOURNAL
2015年
5期
402-405
,共4页
刘艳%王得玲%李卉%陶中娥%梁园%赵琳
劉豔%王得玲%李卉%陶中娥%樑園%趙琳
류염%왕득령%리훼%도중아%량완%조림
侵入性胎盘%粘连性胎盘%植入性胎盘%Endoglin%血管内皮生长因子%滋养细胞
侵入性胎盤%粘連性胎盤%植入性胎盤%Endoglin%血管內皮生長因子%滋養細胞
침입성태반%점련성태반%식입성태반%Endoglin%혈관내피생장인자%자양세포
Placenta accreta%Placenta increta%Endoglin%Vascular endothelial growth factor (VEGF)%Tro-phoblast cell
目的：研究Endoglin和VEGF在侵入性胎盘的表达差异及意义。方法选取我院病理诊断为侵入性胎盘（PA）的胎盘标本30例为研究组，其中包括：20例粘连性胎盘（PA），10例植入性胎盘（PI），选取同期20例正常胎盘（NP）作为对照组，检测的胎盘绒毛滋养细胞中Endoglin和VEGF的表达水平及相关性。结果⑴Endoglin在NP、PA和PI中的阳性表达率分别是35%、80%和90%，Endoglin在PA和PI中阳性表达率明显高于NP，差异有统计学意义（P<0.05）；⑵VEGF在NP、PA和PI中的阳性表达率分别是25%、60%和70%，VEGF在PA和PI中阳性表达率明显高于NP，差异有统计学意义（P<0.05）；⑶经Spearman等级相关检验，Endoglin和VEGF在NP与PA中表达呈正相关(r=0.652，P<0.05)。结论侵入性胎盘的发生发展与胎盘绒毛滋养细胞中Endoglin和VEGF的表达密切相关。
目的：研究Endoglin和VEGF在侵入性胎盤的錶達差異及意義。方法選取我院病理診斷為侵入性胎盤（PA）的胎盤標本30例為研究組，其中包括：20例粘連性胎盤（PA），10例植入性胎盤（PI），選取同期20例正常胎盤（NP）作為對照組，檢測的胎盤絨毛滋養細胞中Endoglin和VEGF的錶達水平及相關性。結果⑴Endoglin在NP、PA和PI中的暘性錶達率分彆是35%、80%和90%，Endoglin在PA和PI中暘性錶達率明顯高于NP，差異有統計學意義（P<0.05）；⑵VEGF在NP、PA和PI中的暘性錶達率分彆是25%、60%和70%，VEGF在PA和PI中暘性錶達率明顯高于NP，差異有統計學意義（P<0.05）；⑶經Spearman等級相關檢驗，Endoglin和VEGF在NP與PA中錶達呈正相關(r=0.652，P<0.05)。結論侵入性胎盤的髮生髮展與胎盤絨毛滋養細胞中Endoglin和VEGF的錶達密切相關。
목적：연구Endoglin화VEGF재침입성태반적표체차이급의의。방법선취아원병리진단위침입성태반（PA）적태반표본30례위연구조，기중포괄：20례점련성태반（PA），10례식입성태반（PI），선취동기20례정상태반（NP）작위대조조，검측적태반융모자양세포중Endoglin화VEGF적표체수평급상관성。결과⑴Endoglin재NP、PA화PI중적양성표체솔분별시35%、80%화90%，Endoglin재PA화PI중양성표체솔명현고우NP，차이유통계학의의（P<0.05）；⑵VEGF재NP、PA화PI중적양성표체솔분별시25%、60%화70%，VEGF재PA화PI중양성표체솔명현고우NP，차이유통계학의의（P<0.05）；⑶경Spearman등급상관검험，Endoglin화VEGF재NP여PA중표체정정상관(r=0.652，P<0.05)。결론침입성태반적발생발전여태반융모자양세포중Endoglin화VEGF적표체밀절상관。
Objective To research the different expressions and significances of endoglin and vascular endothelial growth fac-tor(VEGF) in placenta accreta. Methods 30 pregnant women in the obstetrics department were selected and divided into two groups by placenta pathologic diagnosis. 20 cases were in placenta accrete (PA) group,10 cases were in placenta increta(PI) group. 20 cases of normal pregnant (NP) group were selected as controls. Immunohistochemical SP method was used to detect the expres-sion levels of endoglin and VEGF in placental trophoblast cells of the three study groups. To analysed the result and relationship between the two factors of the three groups. Results ⑴The expression rates of endoglin in NP、PA and PI were 35%,80% and 90%,respectively. The expression rates of endoglin in PA were significantly higher than those in NP ,the differences were statisti-cally significant (P<0.05). ⑵The expression rates of VEGF in NP、PA and PI were 25%,60% and 70%,respectively. The expres-sion rates of VEGF in PA were significantly higher than those in NP,the differences were statistically significant (P<0.05). ⑶The result of Spearman correlation test showed there was a positive correlation of expression levels between Endoglin and VEGF in PA and NP (r=0.652,P<0.05). Conclusion The occurrence and development of placenta accreta was closed relatived with the expres-sions of endoglin and VEGF in placental trophoblast cells.
