CAJ | 학술논문

目的：观察国产醋酸钠林格液与8种常用抗菌药物配伍后的稳定性。方法观察配伍溶液的外观并测定其 pH值、微粒数以及细菌内毒素。结果国产醋酸钠林格液与8种抗菌药物配伍后，样品液均无气体或沉淀产生；pH值、微粒数、色泽在6 h内均无明显改变，室温下放置的配伍液6 h时细菌内毒素检查也符合规定。与左氧氟沙星、哌拉西林钠、头孢呋辛钠、克林霉素、阿昔洛韦、氨曲南、头孢唑啉钠配伍后6 h内相对百分含量均＞90%；与头孢哌酮钠配伍含量下降最大，样品液由浅黄色变成深黄色。结论国产醋酸钠林格液与左氧氟沙星、哌拉西林钠、头孢呋辛钠、克林霉素、阿昔洛韦、氨曲南、头孢唑啉钠可配伍使用，不宜与头孢哌酮钠配伍。
목적：관찰국산작산납림격액여8충상용항균약물배오후적은정성。방법관찰배오용액적외관병측정기 pH치、미립수이급세균내독소。결과국산작산납림격액여8충항균약물배오후，양품액균무기체혹침정산생；pH치、미립수、색택재6 h내균무명현개변，실온하방치적배오액6 h시세균내독소검사야부합규정。여좌양불사성、고랍서림납、두포부신납、극림매소、아석락위、안곡남、두포서람납배오후6 h내상대백분함량균＞90%；여두포고동납배오함량하강최대，양품액유천황색변성심황색。결론국산작산납림격액여좌양불사성、고랍서림납、두포부신납、극림매소、아석락위、안곡남、두포서람납가배오사용，불의여두포고동납배오。
Objective To observe the stabilities of domestic Ringer’s acetate injection mixing with 8 antibiotics.Methods The content changing in 6h of the main content- curcumol in mixed fluid , its value of pH, quantity of motes and bacterial endotoxin were detected by using t he method of ultra-violet spectrophotometry, etc, and to observe the appearance of the mixed lfuid.Results The mixed lfuid produced neither gas nor sediment; the value of pH, quantity of motes and colour did not change markedly in 6h; the detecting of bacterial endotoxin of the mixed lfuid laying up indoors in 6h was suitable after mixing with each drug of 8 antibiotic s respectivel y. The percentage of each quantity of the mix ture was more than 90% after domestic Ringer’s acetate injection was mixed respectively with levolfoxacin, piperacillin sodium, cefuroxime sodium, clindamycin , acyclovir, aztreonam and cephazolin sodium for 6h; the content reduced mostly when domestic Ringer’s acetate injection mixed with cefoperazone sodium and the lfuid changed from light yellow to dark yellow.Conclusion Domestic Ringer’s acetate injection can be used mixing with levofloxacin, piperacillin sodium , cefuroxime sodium, clindamycin, acyclovir, aztreonam and cephazolin sodium;but it can not be used together with cefoperazone sodium.