中国现代药物应用
中國現代藥物應用
중국현대약물응용
CHINESE JOURNAL OF MODERN DRUG APPLICATION
2015年
12期
34-35
,共2页
剖宫产瘢痕部位妊娠%甲氨蝶呤%局部用药%全身用药%米非司酮
剖宮產瘢痕部位妊娠%甲氨蝶呤%跼部用藥%全身用藥%米非司酮
부궁산반흔부위임신%갑안접령%국부용약%전신용약%미비사동
Cesarean scar pregnancy%Methotrexate%Local administration%Systematic administration%Mifepristone
目的：对比甲氨蝶呤(MTX)局部用药与全身用药在联合米非司酮治疗剖宫产瘢痕部位妊娠方面的临床疗效。方法确诊为剖宫产瘢痕部位妊娠的52例保守治疗患者,随机分为观察组和对照组,每组26例,其中观察组采用MTX局部用药联合米非司酮治疗,对照组采用MTX全身用药联合米非司酮治疗。对比两组的治疗效果。结果观察组血人绒毛膜促性腺激素(β-HCG)下降至可行清宫术所需时间平均为(18.0±2.5)d,对照组血β-HCG下降至可行清宫术所需时间平均为(23.0±3.8)d,两组比较差异有统计学意义(P<0.05)。观察组不良反应发生率为11.54%,对照组不良反应发生率为30.77%,两组比较差异有统计学意义(P<0.05)。结论 MTX局部用药联合米非司酮治疗剖宫产瘢痕部位妊娠安全可靠,血β-HCG下降速度较全身用药更快,效果明显,缩短患者治疗时间,且不良反应发生率比全身用药更低,适合在基层医院临床上广泛应用。
目的：對比甲氨蝶呤(MTX)跼部用藥與全身用藥在聯閤米非司酮治療剖宮產瘢痕部位妊娠方麵的臨床療效。方法確診為剖宮產瘢痕部位妊娠的52例保守治療患者,隨機分為觀察組和對照組,每組26例,其中觀察組採用MTX跼部用藥聯閤米非司酮治療,對照組採用MTX全身用藥聯閤米非司酮治療。對比兩組的治療效果。結果觀察組血人絨毛膜促性腺激素(β-HCG)下降至可行清宮術所需時間平均為(18.0±2.5)d,對照組血β-HCG下降至可行清宮術所需時間平均為(23.0±3.8)d,兩組比較差異有統計學意義(P<0.05)。觀察組不良反應髮生率為11.54%,對照組不良反應髮生率為30.77%,兩組比較差異有統計學意義(P<0.05)。結論 MTX跼部用藥聯閤米非司酮治療剖宮產瘢痕部位妊娠安全可靠,血β-HCG下降速度較全身用藥更快,效果明顯,縮短患者治療時間,且不良反應髮生率比全身用藥更低,適閤在基層醫院臨床上廣汎應用。
목적：대비갑안접령(MTX)국부용약여전신용약재연합미비사동치료부궁산반흔부위임신방면적림상료효。방법학진위부궁산반흔부위임신적52례보수치료환자,수궤분위관찰조화대조조,매조26례,기중관찰조채용MTX국부용약연합미비사동치료,대조조채용MTX전신용약연합미비사동치료。대비량조적치료효과。결과관찰조혈인융모막촉성선격소(β-HCG)하강지가행청궁술소수시간평균위(18.0±2.5)d,대조조혈β-HCG하강지가행청궁술소수시간평균위(23.0±3.8)d,량조비교차이유통계학의의(P<0.05)。관찰조불량반응발생솔위11.54%,대조조불량반응발생솔위30.77%,량조비교차이유통계학의의(P<0.05)。결론 MTX국부용약연합미비사동치료부궁산반흔부위임신안전가고,혈β-HCG하강속도교전신용약경쾌,효과명현,축단환자치료시간,차불량반응발생솔비전신용약경저,괄합재기층의원림상상엄범응용。
Objective To compare the clinical effects between local and systematic administration of methotrexate (MTX) combined with mifepristone in the treatment of cesarean scar pregnancy.Methods A total of 52 diagnosed cesarean scar pregnancy patients under conservative treatment were randomly divided into observation group and control group, with 26 cases in each group. The observation group received local administration of MTX combined with mifepristone, and the control group received systematic administration of MTX combined with mifepristone. Curative effects of the two groups were compared.Results The observation group had average time of β-human chorionic gonadotropin (β-HCG) decreased time for curettage was (18.0±2.5) d, and that of the control group was (23.0±3.8) d. The difference between the two groups had statistical significance (P<0.05). Incidence of adverse reactions was 11.54% in the observation group, and that was 30.77% in the control group. Their difference had statistical significance (P<0.05).Conclusion Local administration of MTX combined with mifepristone is safe and reliable in treating cesarean scar pregnancy, and it provides faster decreased serum β-HCG speed, more obvious effect, shorter treatment time, and lower incidence of adverse reactions than systematic administration. This method is suitable for wide application in primary hospital.
