健康研究
健康研究
건강연구
HEALTH RESEARCH
2015年
3期
268-270,273
,共4页
宫颈癌%宫颈上皮内瘤变%年龄%高危型 HPV%液基细胞学
宮頸癌%宮頸上皮內瘤變%年齡%高危型 HPV%液基細胞學
궁경암%궁경상피내류변%년령%고위형 HPV%액기세포학
cervical cancer%cervical intraepithelial neoplasia%age%high-risk human papillomavirus%liquid-based cytology
目的：探讨高危型 HPV 负荷量对宫颈液基细胞学阴性妇女的宫颈上皮内瘤变（ cervical intraepithelial neoplasias，CIN）的诊断价值。方法收集宫颈液基细胞学联合 HC2法检测高危型 HPV－DNA 进行宫颈癌筛查中的细胞学阴性而 HR－HPV 阳性患者526例，并行阴道镜下宫颈活检。分析 HR－HPV 负荷量与宫颈癌及 CIN 的关系。结果526例细胞学阴性、HR－HPV 阳性的患者中，CIN2＋以上病变者共77例，占14．6％。以20～29岁年龄妇女组为参照年龄，30～39、40～49、60～72岁组患 CIN2＋风险高（均 P ＜0．05），在30～39、40～49、50～59岁组中，随着宫颈病变程度加重，HR－HPV－DNA 负荷量随之增加（均 P ＜0．05）。结论30～49岁是 HR－HPV 感染所致宫颈上皮内瘤变的高发年龄；HR－HPV－DNA 负荷量与宫颈上皮内瘤变级别密切相关，HR－HPV－DNA 负荷量越高，患CIN2＋的危险度越高。
目的：探討高危型 HPV 負荷量對宮頸液基細胞學陰性婦女的宮頸上皮內瘤變（ cervical intraepithelial neoplasias，CIN）的診斷價值。方法收集宮頸液基細胞學聯閤 HC2法檢測高危型 HPV－DNA 進行宮頸癌篩查中的細胞學陰性而 HR－HPV 暘性患者526例，併行陰道鏡下宮頸活檢。分析 HR－HPV 負荷量與宮頸癌及 CIN 的關繫。結果526例細胞學陰性、HR－HPV 暘性的患者中，CIN2＋以上病變者共77例，佔14．6％。以20～29歲年齡婦女組為參照年齡，30～39、40～49、60～72歲組患 CIN2＋風險高（均 P ＜0．05），在30～39、40～49、50～59歲組中，隨著宮頸病變程度加重，HR－HPV－DNA 負荷量隨之增加（均 P ＜0．05）。結論30～49歲是 HR－HPV 感染所緻宮頸上皮內瘤變的高髮年齡；HR－HPV－DNA 負荷量與宮頸上皮內瘤變級彆密切相關，HR－HPV－DNA 負荷量越高，患CIN2＋的危險度越高。
목적：탐토고위형 HPV 부하량대궁경액기세포학음성부녀적궁경상피내류변（ cervical intraepithelial neoplasias，CIN）적진단개치。방법수집궁경액기세포학연합 HC2법검측고위형 HPV－DNA 진행궁경암사사중적세포학음성이 HR－HPV 양성환자526례，병행음도경하궁경활검。분석 HR－HPV 부하량여궁경암급 CIN 적관계。결과526례세포학음성、HR－HPV 양성적환자중，CIN2＋이상병변자공77례，점14．6％。이20～29세년령부녀조위삼조년령，30～39、40～49、60～72세조환 CIN2＋풍험고（균 P ＜0．05），재30～39、40～49、50～59세조중，수착궁경병변정도가중，HR－HPV－DNA 부하량수지증가（균 P ＜0．05）。결론30～49세시 HR－HPV 감염소치궁경상피내류변적고발년령；HR－HPV－DNA 부하량여궁경상피내류변급별밀절상관，HR－HPV－DNA 부하량월고，환CIN2＋적위험도월고。
Objective To evaluate the role of high-risk human papillomavirus ( HR-HPV) in detecting cervical intraepithelial neoplasia in women tested as negative with liquid-based cytology.Method A total of 526 women with positive HPV DNA and negative cytology were chosen as the subjects.All cases underwent colposcopic indicated biopsy and pathological diagnosis.Analysis was conducted into the correlation of HR-HPV to cervical cancer and CIN.Findings Of the 526 subjects with positive HPV DNA and negative cytology, 77 (14.6%) were found to have cervical intraepithelial neoplasia of grade 2 or worse (CIN2 +) lesions.Compared with those in the age bracket of 20 ~29 years, the subjects in the age brackets of 30 ~39 years, 40 ~49years, and 60 ~72years had a higher proportion of patients with CIN2 +.The difference was significant (P <0.05).Cervical lesions increased as the HR-HPV-DNA level increased in the women of the age brackets of 30 ~39 years, 40 ~49 years and 50 ~59 years (Pall <0.05).Conclusion The women in the age bracket of 30 to 49 years have the highest risk of suffering cervical intraepithelial neoplasia induced by HR-HPV infection.HR-HPV-DNA level is closely associated with cervical intraepithelial neoplasia.
