CAJ | 학술논문

目的：评价可必特、普米克令舒在使用有创机械通气的重症肺炎患儿中的作用。方法77例重症肺炎患儿随机分成对照组(38例)和实验组(39例)。对照组给予抗感染、机械通气、镇静等治疗，实验组在对照组治疗的基础上给予可必特、普米克令舒雾化治疗。比较两组呼吸机使用时间、喉头水肿持续时间、治疗后血氧分压(PaO2)、二氧化碳分压(PaCO2)。结果实验组呼吸机使用时间短于对照组[(102.7±43.0)h VS (124.1±49.7)h]，喉头水肿持续时间少于对照组[(31.5±11.7)h VS(37.5±13.0)h]，治疗后PaO2较对照组升高[(86.2±11.1)mm Hg VS (78.6±10.4)mm Hg](1mm Hg=0.133 kPa)， PaCO2较对照组下降[(38.5±12.5)mm Hg VS (46.8±13.1)mm Hg]，差异均有统计学意义(P<0.05)。结论机械通气联合可必特、普米克令舒可以有效改善婴幼儿重症肺炎症状、减少机械通气不良反应，值得临床推广应用。
목적：평개가필특、보미극령서재사용유창궤계통기적중증폐염환인중적작용。방법77례중증폐염환인수궤분성대조조(38례)화실험조(39례)。대조조급여항감염、궤계통기、진정등치료，실험조재대조조치료적기출상급여가필특、보미극령서무화치료。비교량조호흡궤사용시간、후두수종지속시간、치료후혈양분압(PaO2)、이양화탄분압(PaCO2)。결과실험조호흡궤사용시간단우대조조[(102.7±43.0)h VS (124.1±49.7)h]，후두수종지속시간소우대조조[(31.5±11.7)h VS(37.5±13.0)h]，치료후PaO2교대조조승고[(86.2±11.1)mm Hg VS (78.6±10.4)mm Hg](1mm Hg=0.133 kPa)， PaCO2교대조조하강[(38.5±12.5)mm Hg VS (46.8±13.1)mm Hg]，차이균유통계학의의(P<0.05)。결론궤계통기연합가필특、보미극령서가이유효개선영유인중증폐염증상、감소궤계통기불량반응，치득림상추엄응용。
Objective To evaluate the effects of combivent and pulmicort respules for severe pneumonia children under invasive mechanical ventilation.Methods A total of 77 children with severe pneumonia were randomly divided into control group (38 cases) and experimental group (39 cases). The control group received treatment as anti-infection, mechanical ventilation, and sedation. The experimental group received additional combivent and pulmicort respules aerosol inhalation. Ventilator use time, laryngeal edema duration, partial pressure of blood oxygen (PaO2) and partial pressure of carbon dioxide (PaCO2) after treatment were compared between the two groups.Results The experimental group had shorter ventilator use time [(102.7±43.0) h VS (124.1±49.7) h], shorter laryngeal edema duration [(31.5±11.7) h VS (37.5±13.0) h], higher PaO2 level after treatment [(86.2±11.1) mm Hg VS (78.6±10.4) mm Hg] (1 mm Hg=0.133 kPa), and lower PaCO2 level [(38.5±12.5) mm Hg VS (46.8±13.1) mm Hg] than the control group, and their differences all had statistical significance (P<0.05).Conclusion Mechanical ventilation combined with combivent and pulmicort respules can effectively improve pediatric severe pneumonia symptoms and reduce adverse reactions of mechanical ventilation. This method is worthy of clinical promotion and application.