CAJ | 학술논문

目的：观察牙龈癌中雌激素受体（ER）与芳香化酶的表达情况，探讨局部雌激素及芳香化酶在牙龈癌中的作用与关系。方法：免疫组化过氧化物酶标记的链酶卵白素法测定雌激素受体及芳香化酶在牙龈癌中的表达。结果：牙龈癌组雌激素受体及芳香化酶的表达阳性率分别为50％和42．86％，正常对照组分别为13．33％和6．67％（P＜0．05）；牙龈癌中雌激素受体与芳香化酶之间未见明显相关性。结论：牙龈癌有一定的雌激素依赖性；芳香化酶在牙龈癌组织中表达升高，但芳香化酶并不是影响局部雌激素受体升高的唯一因素。
목적：관찰아간암중자격소수체（ER）여방향화매적표체정황，탐토국부자격소급방향화매재아간암중적작용여관계。방법：면역조화과양화물매표기적련매란백소법측정자격소수체급방향화매재아간암중적표체。결과：아간암조자격소수체급방향화매적표체양성솔분별위50％화42．86％，정상대조조분별위13．33％화6．67％（P＜0．05）；아간암중자격소수체여방향화매지간미견명현상관성。결론：아간암유일정적자격소의뢰성；방향화매재아간암조직중표체승고，단방향화매병불시영향국부자격소수체승고적유일인소。
AIM:To investigate the expression of estrogen receptor (ER)and aromatase in gingival carcino-ma.METHODS:ER and aromatase were detected by immunohistochemical staining SP method in gingival carcinoma (n=28)and normal gingival tissues(n=15).RESULTS:Positive expression rates of ER and aromatase expression in gingival carcinoma were 50.00% and 42.86% ,in normal gingival tissues were 13.33% and 6.67%,respectively (P<0.05).No significant correlation was found between ER and aromatase in gingival carcinoma.CONCLUSION:Estrogen metablism might be related to gingival carcinoma.Aromatase is not the exclusive reason of the high positive rate of ER.