CAJ | 학술논문

目的：观察胸腺肽α1辅助治疗多重耐药铜绿假单胞菌肺炎的临床疗效。方法选取60例多重耐药铜绿假单胞菌肺炎患者作为研究对象，随机分为观察组和对照组，每组30例。对照组予以常规治疗，观察组在常规治疗的基础上予以胸腺肽α1辅助治疗。监测治疗前后降钙素原( PCT)、白细胞数量( WBC)、C-反应蛋白( CRP)及T 淋巴细胞亚群水平，并统计两组患者的住院时间和临床疗效。结果治疗前后两组患者的炎症指标和临床症状均得到了改善，与对照组相比，观察组各炎症指标得到了更好的改善(P<0．05)，免疫功能亦得到了提高，取得了更好的临床疗效。结论常规抗感染治疗辅以胸腺肽α1肌肉注射能提高患者自身免疫状况、改善患者的临床症状进而提高抗感染治疗的效果，值得临床推广。
목적：관찰흉선태α1보조치료다중내약동록가단포균폐염적림상료효。방법선취60례다중내약동록가단포균폐염환자작위연구대상，수궤분위관찰조화대조조，매조30례。대조조여이상규치료，관찰조재상규치료적기출상여이흉선태α1보조치료。감측치료전후강개소원( PCT)、백세포수량( WBC)、C-반응단백( CRP)급T 림파세포아군수평，병통계량조환자적주원시간화림상료효。결과치료전후량조환자적염증지표화림상증상균득도료개선，여대조조상비，관찰조각염증지표득도료경호적개선(P<0．05)，면역공능역득도료제고，취득료경호적림상료효。결론상규항감염치료보이흉선태α1기육주사능제고환자자신면역상황、개선환자적림상증상진이제고항감염치료적효과，치득림상추엄。
Objective To observe the clinical curative effect of thymosin alpha 1 in the treatment of multi-drug resistant Pseudomonas aeruginosa pneumonia. Methods 60 patients with multi-drug resistant Pseudomonas aeruginosa pneumonia were randomly divided into the observation group and the control group, 30 cases in each group. The control group was given conventional treatment, while thymosin alpha 1 was added to the observation group on the basis of conventional treatment. Before and after the treatment, procalcitonin ( PCT) , white blood cell count ( WBC) , C-reactive protein ( CRP) and T lymphocyte subpopulation were detected, as well as the hospitaliza-tion time and clinical efficacy in two groups. Results Inflammatory indexes and clinical symptoms improved after the treatment in the two groups, and the improvement was more pronounced in the observation group than in the control group (P<0. 05). The observation group had better clinical curative effect than the control group did. Conclusion Conventional anti-infection treatment combined with thymosin alpha 1 intramuscular injection can efficiently im-prove autoimmune conditions, clinical symptoms, as well as the effect of treatment of anti-infection.