CAJ | 학술논문

以β-丁内酯（BL）为单体、萘钾-冠醚为引发剂通过阴离子开环聚合合成聚（β-丁内酯）（PHB），研究了反应时间对 PHB 分子量的影响。在萘钾-冠醚引发体系的基础上制备聚乙二醇甲醚-钾大分子引发剂（mPEG-K），采用 mPEG-K 引发β-丁内酯开环聚合合成两亲性嵌段共聚物聚乙二醇甲醚-聚（β-丁内酯）（mPEG-PHB），并通过1 HNMR、FTIR、DSC 对其进行表征。通过分子自组装技术制备了 mPEG-PHB 共聚物的纳米粒子，采用 SEM、TEM、DLS 对纳米粒子进行表征。结果表明，在一定时间内 PHB 的分子量随反应时间的延长而增大。DSC 结果表明，无定形的 PHB 明显降低了结晶性 mPEG 的结晶能力。mPEG-PHB 纳米粒子为粒径在100 nm 左右的具有核壳结构的纳米微球。
이β-정내지（BL）위단체、내갑-관미위인발제통과음리자개배취합합성취（β-정내지）（PHB），연구료반응시간대 PHB 분자량적영향。재내갑-관미인발체계적기출상제비취을이순갑미-갑대분자인발제（mPEG-K），채용 mPEG-K 인발β-정내지개배취합합성량친성감단공취물취을이순갑미-취（β-정내지）（mPEG-PHB），병통과1 HNMR、FTIR、DSC 대기진행표정。통과분자자조장기술제비료 mPEG-PHB 공취물적납미입자，채용 SEM、TEM、DLS 대납미입자진행표정。결과표명，재일정시간내 PHB 적분자량수반응시간적연장이증대。DSC 결과표명，무정형적 PHB 명현강저료결정성 mPEG 적결정능력。mPEG-PHB 납미입자위립경재100 nm 좌우적구유핵각결구적납미미구。
Usingβ-butyrolactone(BL)as monomer,naphthalene potassium-crown ether as initiator,poly(β-butyrolactone)(PHB)was synthesized by anionic ring-opening polymerization.The effect of reaction time on molecular weight of PHB was studied.Poly(ethylene glycol)methyl ether-potassium macroinitiators(mPEG-K) was synthesized based on naphthalene potassium-crown ether.Amphiphilic poly(ethylene glycol)methyl ether-poly(β-butyrolactone)(mPEG-PHB)was prepared by ring-opening polymerization of BL initiated by mPEG-K. Copolymer was characterized by 1 HNMR,FTIR,DSC.The copolymer nanoparticles were prepared by the mo-lecular self-assemble technology.These nanoparticles were characterized by SEM,TEM,DLS.The results showed that the molecular weight of PHB increased with reaction time in a certain time.The DSC results showed that amorphous PHB reduced the crystallization ability of mPEG significantly.These nanoparticles were core-shell structure nanospheres with size of 100 nm.