CAJ | 학술논문

为了获得结构和性能更加接近天然卟啉的合成卟啉化合物，采用 Fmoc 保护氨基酸（甘氨酸、缬氨酸、L-酪氨酸），将氨基酸引入卟啉体系，设计合成了系列新型卟啉-氨基酸化合物，并对其光谱性能进行了研究。结果表明，在合成以酯键相连的卟啉-氨基酸化合物时，甘氨酸、缬氨酸反应生成含有2个氨基酸单元的化合物，L-酪氨酸生成含1个氨基酸单元的化合物。在合成以酰胺键相连的化合物时，反应得到含有1个氨基酸单元的化合物。卟啉的光谱性能不因不同 Fmoc 保护氨基酸单元的引入而改变。
위료획득결구화성능경가접근천연계람적합성계람화합물，채용 Fmoc 보호안기산（감안산、힐안산、L-락안산），장안기산인입계람체계，설계합성료계렬신형계람-안기산화합물，병대기광보성능진행료연구。결과표명，재합성이지건상련적계람-안기산화합물시，감안산、힐안산반응생성함유2개안기산단원적화합물，L-락안산생성함1개안기산단원적화합물。재합성이선알건상련적화합물시，반응득도함유1개안기산단원적화합물。계람적광보성능불인불동 Fmoc 보호안기산단원적인입이개변。
To obtain the porphyrins similar to the natural ones in structure and properties,novel porphyrin-amino acid adduct protected by Fmoc were synthesized and their spectral properties were investigated.Results showed that,two amino acid units porphyrin adducts(with glycine,valine)and one amino acid unit prophyrine adduct(with L-tyrosin)were obtained when Fmoc-amino acid reacted with hydroxy porphyrins by ester bond. Porphyrin adducts containing one amino acid unit were formed when Fmoc-amino acid was condensed with aminoporphyrins by amide bond.The introduction of different Fmoc-amino acids had litttle influence on spectral properties of porphyrins.