中国医学前沿杂志（电子版）
中國醫學前沿雜誌（電子版）
중국의학전연잡지（전자판）
CHINESE JOURNAL OF THE FRONTIERS OF MEDICAL SCIENCE(ELECTRONIC VERSION)
2015年
4期
106-108
,共3页
多囊卵巢综合征%激素%子宫内膜%屈螺酮炔雌醇片%来曲唑
多囊卵巢綜閤徵%激素%子宮內膜%屈螺酮炔雌醇片%來麯唑
다낭란소종합정%격소%자궁내막%굴라동결자순편%래곡서
Polycystic ovary syndrome%Hormone%Endometrium%Drospirenone and ethinylestradiol tablets%Letrozole
目的：探讨屈螺酮炔雌醇片预处理后采用来曲唑治疗多囊卵巢综合征不孕患者的临床效果。方法选择本院2012年12月至2013年6月诊治的120例多囊卵巢综合征不孕患者作为研究对象，随机分为两组，对照组59例患者采用来曲唑治疗，观察组61例患者接受屈螺酮炔雌醇片预处理后采用来曲唑治疗。观察两组患者治疗前后激素水平变化，包括促黄体生成素（LH）、促卵泡刺激素（FSH）、睾酮（T）、雌二醇（E2）；比较两组患者治疗后的排卵率、妊娠率以及人绒毛膜促性腺激素（HCG）注射日子宫内膜厚度。结果两组患者治疗前LH、FSH、LH/FSH、T、E2水平比较差异均无显著性（P＞0.05），治疗后观察组患者LH、LH/FSH、T水平较治疗前显著降低（P＜0.05），对照组患者上述指标较治疗前有所下降，但差异无显著性（P＞0.05），两组间上述指标比较差异均有显著性（P＜0.05）。观察组患者HCG注射日子宫内膜平均厚度为（8.92±1.14）mm，明显大于对照组[（8.53±1.22） mm]，但差异无显著性（t＝1.81，P＞0.05）；观察组患者排卵率、妊娠率均显著高于对照组（P＜0.05）。结论屈螺酮炔雌醇片预处理后采用来曲唑治疗多囊卵巢综合征不孕患者的临床效果显著，能够改善患者的激素水平，提高排卵率及妊娠率，是有效的临床治疗方案。
目的：探討屈螺酮炔雌醇片預處理後採用來麯唑治療多囊卵巢綜閤徵不孕患者的臨床效果。方法選擇本院2012年12月至2013年6月診治的120例多囊卵巢綜閤徵不孕患者作為研究對象，隨機分為兩組，對照組59例患者採用來麯唑治療，觀察組61例患者接受屈螺酮炔雌醇片預處理後採用來麯唑治療。觀察兩組患者治療前後激素水平變化，包括促黃體生成素（LH）、促卵泡刺激素（FSH）、睪酮（T）、雌二醇（E2）；比較兩組患者治療後的排卵率、妊娠率以及人絨毛膜促性腺激素（HCG）註射日子宮內膜厚度。結果兩組患者治療前LH、FSH、LH/FSH、T、E2水平比較差異均無顯著性（P＞0.05），治療後觀察組患者LH、LH/FSH、T水平較治療前顯著降低（P＜0.05），對照組患者上述指標較治療前有所下降，但差異無顯著性（P＞0.05），兩組間上述指標比較差異均有顯著性（P＜0.05）。觀察組患者HCG註射日子宮內膜平均厚度為（8.92±1.14）mm，明顯大于對照組[（8.53±1.22） mm]，但差異無顯著性（t＝1.81，P＞0.05）；觀察組患者排卵率、妊娠率均顯著高于對照組（P＜0.05）。結論屈螺酮炔雌醇片預處理後採用來麯唑治療多囊卵巢綜閤徵不孕患者的臨床效果顯著，能夠改善患者的激素水平，提高排卵率及妊娠率，是有效的臨床治療方案。
목적：탐토굴라동결자순편예처리후채용래곡서치료다낭란소종합정불잉환자적림상효과。방법선택본원2012년12월지2013년6월진치적120례다낭란소종합정불잉환자작위연구대상，수궤분위량조，대조조59례환자채용래곡서치료，관찰조61례환자접수굴라동결자순편예처리후채용래곡서치료。관찰량조환자치료전후격소수평변화，포괄촉황체생성소（LH）、촉란포자격소（FSH）、고동（T）、자이순（E2）；비교량조환자치료후적배란솔、임신솔이급인융모막촉성선격소（HCG）주사일자궁내막후도。결과량조환자치료전LH、FSH、LH/FSH、T、E2수평비교차이균무현저성（P＞0.05），치료후관찰조환자LH、LH/FSH、T수평교치료전현저강저（P＜0.05），대조조환자상술지표교치료전유소하강，단차이무현저성（P＞0.05），량조간상술지표비교차이균유현저성（P＜0.05）。관찰조환자HCG주사일자궁내막평균후도위（8.92±1.14）mm，명현대우대조조[（8.53±1.22） mm]，단차이무현저성（t＝1.81，P＞0.05）；관찰조환자배란솔、임신솔균현저고우대조조（P＜0.05）。결론굴라동결자순편예처리후채용래곡서치료다낭란소종합정불잉환자적림상효과현저，능구개선환자적격소수평，제고배란솔급임신솔，시유효적림상치료방안。
Objective To investigate the clinical efficacy of Letrozole treatment after Drospirenone and ethinylestradiol tablets pretreatment in infertility patients with polycystic ovary syndrome. Method 120 cases of infertility patients caused by polycystic ovary syndrome from December 2012 to June 2013 in our hospital were selected as the study objects and they were randomly divided into two groups, 59 cases in the control group were treated with Letrozole, 61 cases in the observation group were treated with Letrozole treatment after Drospirenone and ethinylestradiol tablets pretreatment, the changes of hormone levels in the two groups were compared before and after treatment, included luteinizing hormone (LH), follicle-stimulating hormone (FSH), testosterone (T), estradiol (E2);the ovulation rate, pregnancy rate and endometrial thickness of two groups were compared. Result Before treatment, the patients LH, FSH, LH/FSH, T, E2 levels had no signiifcant differences between two groups (P>0.05), after treatment, the patients LH, LH/FSH, T levels in observation group were signiifcantly reduced, compared with before treatment, the differences were statistically signiifcant (P<0.05), the index of control group had declined, but compared with before treatment the differences had no statistically signiifcant (P > 0.05), the LH, LH/FSH, T levels of observation group and control group had signiifcantly different (P< 0.05);after treatment, the average endometrial thickness of HCG injection day of observation group was (8.92±1.14) mm, signiifcantly greater than control group [(8.53±1.22) mm ], but the difference was not statistically signiifcant between two groups (t = 1.81, P > 0.05), and the ovulation rate, pregnancy rate in observation group were signiifcantly higher than control group, the differences were statistically signiifcant between two groups (P < 0.05). Conclusion Letrozole treatment after Drospirenone and ethinylestradiol tablets pretreatment in infertility patients with polycystic ovary syndrome has signiifcant clinical effect, it can improve hormone levels, increase the ovulation rate, pregnancy rate, so it is an effective clinical treatment.
