中国医学前沿杂志（电子版）
中國醫學前沿雜誌（電子版）
중국의학전연잡지（전자판）
CHINESE JOURNAL OF THE FRONTIERS OF MEDICAL SCIENCE(ELECTRONIC VERSION)
2015年
4期
94-97
,共4页
腹腔热疗%TP方案%中晚期卵巢癌%免疫功能
腹腔熱療%TP方案%中晚期卵巢癌%免疫功能
복강열료%TP방안%중만기란소암%면역공능
Intraperitoneal hyperthermia%TP regimen%Advanced ovarian cancer%Immune function
目的：探讨腹腔热疗与紫杉醇联合顺铂（TP）方案对中晚期卵巢癌患者免疫功能的影响。方法选取本院2012年5月至2014年5月收治的117例中晚期卵巢癌患者作为研究对象，按照随机数表法分为观察组（n＝58）及对照组（n＝59），两组患者均给予TP方案化疗，观察组患者在此基础上加用腹腔热疗，比较两组患者近期疗效，治疗后外周血CD3＋、CD4＋、CD8＋T淋巴细胞水平及CD4＋/CD8＋比值的变化及不良反应发生情况。结果观察组患者治疗有效率为74.1%（43/58），对照组为50.8%（30/59），观察组近期疗效显著优于对照组（P＜0.05）。观察组患者白细胞减少、恶心呕吐及过敏反应的发生率明显低于对照组（P＜0.05），两组患者肝损伤发生率比较差异无显著性（P＞0.05）。观察组患者治疗后CD3＋、CD4＋T淋巴细胞水平及CD4＋/CD8＋比值显著升高，CD8＋T淋巴细胞水平显著下降（P＜0.05），对照组患者治疗后CD4＋T淋巴细胞水平升高，CD8＋T淋巴细胞水平及CD4＋/CD8＋比值显著降低（P＜0.05）；观察组治疗后CD3＋、CD4＋T淋巴细胞水平及CD4＋/CD8＋比值显著高于对照组，CD8＋T淋巴细胞水平低于对照组，差异具有显著性（P＜0.05）。结论腹腔热疗联合TP方案在中晚期卵巢癌的治疗中发挥了较佳的效果，在提高患者近期疗效的同时还有助于改善其免疫功能，远期预后以及影响机制仍有待进一步研究证实。
目的：探討腹腔熱療與紫杉醇聯閤順鉑（TP）方案對中晚期卵巢癌患者免疫功能的影響。方法選取本院2012年5月至2014年5月收治的117例中晚期卵巢癌患者作為研究對象，按照隨機數錶法分為觀察組（n＝58）及對照組（n＝59），兩組患者均給予TP方案化療，觀察組患者在此基礎上加用腹腔熱療，比較兩組患者近期療效，治療後外週血CD3＋、CD4＋、CD8＋T淋巴細胞水平及CD4＋/CD8＋比值的變化及不良反應髮生情況。結果觀察組患者治療有效率為74.1%（43/58），對照組為50.8%（30/59），觀察組近期療效顯著優于對照組（P＜0.05）。觀察組患者白細胞減少、噁心嘔吐及過敏反應的髮生率明顯低于對照組（P＜0.05），兩組患者肝損傷髮生率比較差異無顯著性（P＞0.05）。觀察組患者治療後CD3＋、CD4＋T淋巴細胞水平及CD4＋/CD8＋比值顯著升高，CD8＋T淋巴細胞水平顯著下降（P＜0.05），對照組患者治療後CD4＋T淋巴細胞水平升高，CD8＋T淋巴細胞水平及CD4＋/CD8＋比值顯著降低（P＜0.05）；觀察組治療後CD3＋、CD4＋T淋巴細胞水平及CD4＋/CD8＋比值顯著高于對照組，CD8＋T淋巴細胞水平低于對照組，差異具有顯著性（P＜0.05）。結論腹腔熱療聯閤TP方案在中晚期卵巢癌的治療中髮揮瞭較佳的效果，在提高患者近期療效的同時還有助于改善其免疫功能，遠期預後以及影響機製仍有待進一步研究證實。
목적：탐토복강열료여자삼순연합순박（TP）방안대중만기란소암환자면역공능적영향。방법선취본원2012년5월지2014년5월수치적117례중만기란소암환자작위연구대상，안조수궤수표법분위관찰조（n＝58）급대조조（n＝59），량조환자균급여TP방안화료，관찰조환자재차기출상가용복강열료，비교량조환자근기료효，치료후외주혈CD3＋、CD4＋、CD8＋T림파세포수평급CD4＋/CD8＋비치적변화급불량반응발생정황。결과관찰조환자치료유효솔위74.1%（43/58），대조조위50.8%（30/59），관찰조근기료효현저우우대조조（P＜0.05）。관찰조환자백세포감소、악심구토급과민반응적발생솔명현저우대조조（P＜0.05），량조환자간손상발생솔비교차이무현저성（P＞0.05）。관찰조환자치료후CD3＋、CD4＋T림파세포수평급CD4＋/CD8＋비치현저승고，CD8＋T림파세포수평현저하강（P＜0.05），대조조환자치료후CD4＋T림파세포수평승고，CD8＋T림파세포수평급CD4＋/CD8＋비치현저강저（P＜0.05）；관찰조치료후CD3＋、CD4＋T림파세포수평급CD4＋/CD8＋비치현저고우대조조，CD8＋T림파세포수평저우대조조，차이구유현저성（P＜0.05）。결론복강열료연합TP방안재중만기란소암적치료중발휘료교가적효과，재제고환자근기료효적동시환유조우개선기면역공능，원기예후이급영향궤제잉유대진일보연구증실。
Objective To explore the treatment on the immune function of patients with advanced ovarian cancer peritoneal hyperthermia combined with TP regimen. Method Selected the hospital from May 2012 to May 2014, 117 patients with advanced ovarian cancer, according to a random number table method divided into observation group (n=58) and control group (n=59). The two groups of patients were given TP chemotherapy, patients in observation group were based on the use of intraperitoneal hyperthermia. Compared the two groups of patients with curative effect in the near future, the occurrence of changes of peripheral blood CD3+, CD4+, CD8 +T lymphocyte levels and CD4 +/CD8 +ratio and adverse reactions. Result The effective rate of observation group was 74.1%(43/58), control group was 50.8%(30/59), the observation group curative effect was signiifcantly better than control group (P < 0.05). Observation group with nausea and vomiting, allergic reactions, neutropenia incidence were significantly lower than control group (P < 0.05), the two groups of patients with liver injury rate had no signiifcant difference (P>0.05). After treatment observation group patients with CD3+, CD4+T lymphocyte levels, CD4+/CD8+ratio were increased signiifcantly, CD8+T lymphocyte level was signiifcantly decreased (P < 0.05), control group after treatment in patients with elevated levels of CD4+, CD8+T lymphocyte and CD4+/CD8+ratio were signiifcantly decreased (P<0.05);observation group after treatment CD3+, CD4+T lymphocyte levels and CD4+/CD8+ratio were signiifcantly higher than control group, the level of CD8+T lymphocyte was lower than control group (P<0.05). Conclusion Intraperitoneal hyperthermia combineal with TP regimen play a better results of treatment in advanced ovarian cancer, in improving the prognosis and helps the improvement of immune function, the long-term prognosis and inlfuencing mechanism remains to be conifrmed by further studies.
