CAJ | 학술논문

目的研究分析62例原发纵隔大B细胞淋巴瘤患者的临床特征。方法选取本院2013年1月至2014年3月收治的原发纵隔大B细胞淋巴瘤患者62例为研究对象，整理分析所有入选患者的临床资料、临床表现及病理特征，并进行随访，全面分析患者病情变化情况。结果影响患者预后的不良因素有：患有上腔静脉综合征、未行放射治疗或未行靶向治疗、机体乳酸脱氢酶水平相对较高。治疗方式的不同亦影响患者的预后。62例患者经相应治疗后，完全缓解9例，部分缓解48例，无效5例。结论原发纵隔大B细胞淋巴瘤多发于男性，影像学表现以出现纵隔肿块且压迫周围组织器官为主。采用放射治疗＋利妥昔单抗＋CHOP方案治疗原发纵隔大B细胞淋巴瘤具有较明显的效果。
목적연구분석62례원발종격대B세포림파류환자적림상특정。방법선취본원2013년1월지2014년3월수치적원발종격대B세포림파류환자62례위연구대상，정리분석소유입선환자적림상자료、림상표현급병리특정，병진행수방，전면분석환자병정변화정황。결과영향환자예후적불량인소유：환유상강정맥종합정、미행방사치료혹미행파향치료、궤체유산탈경매수평상대교고。치료방식적불동역영향환자적예후。62례환자경상응치료후，완전완해9례，부분완해48례，무효5례。결론원발종격대B세포림파류다발우남성，영상학표현이출현종격종괴차압박주위조직기관위주。채용방사치료＋리타석단항＋CHOP방안치료원발종격대B세포림파류구유교명현적효과。
Objective Research and analysis of 62 patients with primary mediastinal large B-cell lymphoma clinical features. Method From January 2013 to March 2014, selected our hospital 62 cases patients with primary mediastinal large B-cell lymphoma as the research objects, and analysed the clinical data, clinical manifestations and pathological features of all the patients, followed-up and comprehensive analyzed the changes of condition. Result The adverse factors inlfuencing the prognosis of patients were superior vena cava syndrome, not to take targeted therapy, not to take radiation therapy or relatively high levels of lactate dehydrogenase. And the different methods of treatment also affected the prognosis of patients. After treatment 62 patients with complete remission 9 cases, partial remission 48 cases, invalid 5 cases. Conclusion Primary mediastinal large B-cell lymphoma are more common in male, major clinical manifestations of iconography are appearing mediastinal mass and constricting surrounding tissues and organs. Radiotherapy+rituximab+CHOP as the treatment for primary mediastinal large B-cell lymphoma have a more signiifcant effect.