中国医学前沿杂志(电子版)
中國醫學前沿雜誌(電子版)
중국의학전연잡지(전자판)
CHINESE JOURNAL OF THE FRONTIERS OF MEDICAL SCIENCE(ELECTRONIC VERSION)
2015年
4期
62-64
,共3页
ω-3鱼油脂肪乳%克罗恩病%梗阻型%效果
ω-3魚油脂肪乳%剋囉恩病%梗阻型%效果
ω-3어유지방유%극라은병%경조형%효과
ω-3 PUFA%Crohn's disease%Obstruction type%Effect
目的探讨ω-3鱼油脂肪乳(ω-3 PUFA)治疗活动性梗阻型克罗恩病的临床效果。方法选取2010年10月至2013年10月本院收治的活动性梗阻型克罗恩病患者80例作为研究对象,根据患者采用肠外营养联合糖皮质激素或ω-3 PUFA将其分为对照组和研究组,每组各40例。比较两组患者诱导缓解治疗情况、并发症发生情况和耐受全肠内营养时间。结果对照组患者诱导缓解治疗时间为(32.1±0.6)天,诱导成功例数为28例,克罗恩病活动指数(CDAI)评分为(107.8±23.5)分,C反应蛋白(CRP)水平为(7.8±0.8)mg/L,与研究组比较差异均具有显著性(P<0.05)。研究组患者并发症发生率为12.5%(5/40),明显低于对照组[30.0%(12/40)],耐受全肠内营养时间为(25.02±0.83)天,明显少于对照组[(30.28±1.37)天],差异均具有显著性(P<0.05)。结论与肠外营养联合糖皮质激素相比,肠外营养联合ω-3 PUFA的诱导缓解治疗时间更短,成功率更高,并发症更少,对活动性梗阻型克罗恩患者的治疗效果更好,值得临床推广应用。
目的探討ω-3魚油脂肪乳(ω-3 PUFA)治療活動性梗阻型剋囉恩病的臨床效果。方法選取2010年10月至2013年10月本院收治的活動性梗阻型剋囉恩病患者80例作為研究對象,根據患者採用腸外營養聯閤糖皮質激素或ω-3 PUFA將其分為對照組和研究組,每組各40例。比較兩組患者誘導緩解治療情況、併髮癥髮生情況和耐受全腸內營養時間。結果對照組患者誘導緩解治療時間為(32.1±0.6)天,誘導成功例數為28例,剋囉恩病活動指數(CDAI)評分為(107.8±23.5)分,C反應蛋白(CRP)水平為(7.8±0.8)mg/L,與研究組比較差異均具有顯著性(P<0.05)。研究組患者併髮癥髮生率為12.5%(5/40),明顯低于對照組[30.0%(12/40)],耐受全腸內營養時間為(25.02±0.83)天,明顯少于對照組[(30.28±1.37)天],差異均具有顯著性(P<0.05)。結論與腸外營養聯閤糖皮質激素相比,腸外營養聯閤ω-3 PUFA的誘導緩解治療時間更短,成功率更高,併髮癥更少,對活動性梗阻型剋囉恩患者的治療效果更好,值得臨床推廣應用。
목적탐토ω-3어유지방유(ω-3 PUFA)치료활동성경조형극라은병적림상효과。방법선취2010년10월지2013년10월본원수치적활동성경조형극라은병환자80례작위연구대상,근거환자채용장외영양연합당피질격소혹ω-3 PUFA장기분위대조조화연구조,매조각40례。비교량조환자유도완해치료정황、병발증발생정황화내수전장내영양시간。결과대조조환자유도완해치료시간위(32.1±0.6)천,유도성공례수위28례,극라은병활동지수(CDAI)평분위(107.8±23.5)분,C반응단백(CRP)수평위(7.8±0.8)mg/L,여연구조비교차이균구유현저성(P<0.05)。연구조환자병발증발생솔위12.5%(5/40),명현저우대조조[30.0%(12/40)],내수전장내영양시간위(25.02±0.83)천,명현소우대조조[(30.28±1.37)천],차이균구유현저성(P<0.05)。결론여장외영양연합당피질격소상비,장외영양연합ω-3 PUFA적유도완해치료시간경단,성공솔경고,병발증경소,대활동성경조형극라은환자적치료효과경호,치득림상추엄응용。
Objective To explore the application results of the Omega-3 polyunsaturated fatty acid (ω-3 PUFA) therapeutic in active obstruction type Crohn's disease. Method 80 patients with active obstruction type Crohn's disease were selected from October 2010 to October 2013 in our hospital, and divided into control group and study group according to parenteral nutrition combined with GCS orω-3 PUFA, 40 cases in each group. Compared two groups of patients with remission induction therapy, complications, total enteral nutrition time. Result The remission induction treatment time in the control group was (32.1±0.6) days, the number of cases for the successful induction was 28 cases, CDAI score was (107.8±23.5) points, CRP was (7.8±0.8) mg/L, compared with study group, the differences were signiifcant (P < 0.05). The complication rate in study group was 12.5%(5/40), signiifcantly lower than control group [30.0%(12/40)], total enteral nutrition time was (25.02±0.83) days, signiifcantly less than control group [(30.28±1.37) days], the differences were statistically signiifcant (P<0.05). Conclusion Compared with parenteral nutrition combined with GCS,ω-3 PUFA combined with parenteral nutrition has shorter remission treatment times, higher success rates, fewer complications, the treatment effect in patients with active obstruction type Crohn's disease more good, worthy of clinical application.