临床与病理杂志
臨床與病理雜誌
림상여병리잡지
International Journal of Pathology and Clinical Medicine
2015年
5期
869-872
,共4页
冯晓雪(综述)%刘丹彦(审校)
馮曉雪(綜述)%劉丹彥(審校)
풍효설(종술)%류단언(심교)
Shh信号通路%痛觉敏化%胶质细胞%炎症因子%突触可塑性
Shh信號通路%痛覺敏化%膠質細胞%炎癥因子%突觸可塑性
Shh신호통로%통각민화%효질세포%염증인자%돌촉가소성
Shh signaling pathways%pain sensitization%glial cells%infammatory factors%synaptic plasticity
神经病理性痛是一种由于躯体感觉神经系统的损伤或疾病而直接造成的疼痛。Sonic hedgehog(Shh)信号转导通路是经典的控制胚胎发育的信号转导途径。近年来发现，该信号途径不仅参与胚胎神经系统模式发育，在成熟机体的稳态调节中也发挥重要作用，因此正逐渐成为信号转导领域新的研究热点。最新文献表明，Shh通路调节神经病理性疼痛的痛觉敏化，且其可能机制与星形胶质细胞激活，炎症因子以及突触可塑性的改变相关。
神經病理性痛是一種由于軀體感覺神經繫統的損傷或疾病而直接造成的疼痛。Sonic hedgehog(Shh)信號轉導通路是經典的控製胚胎髮育的信號轉導途徑。近年來髮現，該信號途徑不僅參與胚胎神經繫統模式髮育，在成熟機體的穩態調節中也髮揮重要作用，因此正逐漸成為信號轉導領域新的研究熱點。最新文獻錶明，Shh通路調節神經病理性疼痛的痛覺敏化，且其可能機製與星形膠質細胞激活，炎癥因子以及突觸可塑性的改變相關。
신경병이성통시일충유우구체감각신경계통적손상혹질병이직접조성적동통。Sonic hedgehog(Shh)신호전도통로시경전적공제배태발육적신호전도도경。근년래발현，해신호도경불부삼여배태신경계통모식발육，재성숙궤체적은태조절중야발휘중요작용，인차정축점성위신호전도영역신적연구열점。최신문헌표명，Shh통로조절신경병이성동통적통각민화，차기가능궤제여성형효질세포격활，염증인자이급돌촉가소성적개변상관。
Neuropathy pain is a kind of pain due to injury or disease to the body of sensory nerve system. Sonic hedgehog (Shh) signal transduction pathway is a classic control signal transduction pathways in embryonic development. And it be found that the signaling pathways involved in the development of the nervous system model in mature steady state, so is becoming a hot spot in the ifeld of new signal transduction. Novel studies have demonstrated that the Shh pathway is associated with pain sensitization in neuropathy pain. And its mechanism maybe about astrocyte activation, inlfammation factors and the change of the synaptic plasticity.
