CAJ | 학술논문

目的：探讨肺原发性脑膜瘤的临床病理特征、诊断和鉴别诊断、治疗及预后。方法：回顾性分析1例肺原发性脑膜瘤患者的临床资料、组织病理形态、免疫组织化学染色、治疗及随访结果，并回顾相关文献。结果：光镜下肿瘤细胞呈短梭形，细胞呈漩涡状排列，细胞异型性不明显，未见明确核分裂象。免疫组织化学染色结果显示肿瘤细胞胞浆AE1/AE3、CK8/18灶状(+)、EMA(+)， S100、SMA、TTF-1、CD34、CD31、PR、ALK、Syn均(–)，Ki-67阳性率约1%。组织学和免疫组织化学染色结果均支持良性脑膜瘤的诊断。结论：肺原发性脑膜瘤十分少见，掌握其临床病理特征对该病的诊断、鉴别诊断、治疗及预后具有重要意义。
목적：탐토폐원발성뇌막류적림상병리특정、진단화감별진단、치료급예후。방법：회고성분석1례폐원발성뇌막류환자적림상자료、조직병리형태、면역조직화학염색、치료급수방결과，병회고상관문헌。결과：광경하종류세포정단사형，세포정선와상배렬，세포이형성불명현，미견명학핵분렬상。면역조직화학염색결과현시종류세포포장AE1/AE3、CK8/18조상(+)、EMA(+)， S100、SMA、TTF-1、CD34、CD31、PR、ALK、Syn균(–)，Ki-67양성솔약1%。조직학화면역조직화학염색결과균지지량성뇌막류적진단。결론：폐원발성뇌막류십분소견，장악기림상병리특정대해병적진단、감별진단、치료급예후구유중요의의。
Objective:To investigate the clinical and pathological features, diagnosis and differential diagnosis, treatment and prognosis of primary pulmonary meningioma. Methods:Retrospective analysis of the clinical data was conducted in one case of primary pulmonary meningioma, and the histopathological morphology, immunohistochemistry staining, treatment and follow-up data, and related literatures. Results:Under light microscope, it disclosed a tumor compressing the adjacent lung parenchyma. At higher magniifcation the lesion was composed of nests of polygonal to spindle-shaped cells arranged in fascicles or whorls. hTere was no pleomorphism, mitotic ifgures were also absent. Immunohistochemically, revealed spottily positivity for AE1/AE3 , CK8/18, and a strong positivity for EMA. S100, SMA, TTF-1, CD34, CD31, PR, ALK and Syn were all negative. Ki-67-positive rate was about 1%. hTe histological and immunohistochemical features strongly suggested the diagnosis of benign meningioma. Conclusion:The incidence of primary pulmonary meningioma is very low, therefore, grasp the clinical and pathological features of the disease, will play an important role in the diagnosis, differential diagnosis, treatment and prognosis of it.