CAJ | 학술논문

目的：应用Logistic回归和ROC曲线探讨血清癌胚抗原( CEA)、鳞状细胞癌抗原( SCC-Ag)和铁蛋白( SF)检测在肺癌淋巴结转移中的诊断价值。方法分别检测100例手术前肺癌患者血清中三种肿瘤标志物水平,行手术确定淋巴结转移情况,通过Logistic回归建立回归模型,用ROC曲线分析三项指标对肺癌淋巴结转移的价值。结果淋巴结有转移组CEA、SCC-Ag的阳性率显著高于无转移组(P<0．01,P<0．05),而SF在两组间的阳性率比较差异无统计学意义(P >0．05)；建立回归模型 Y =1/[1+EXP(1．584X1+0．935X2-0．425)],新变量Y的AUC高于三种单一肿瘤标志物的 AUC。结论综合运用 Logistic回归和ROC曲线分析CEA、SCC-Ag和SF对肺癌淋巴结转移的诊断具有较高的价值,可提高其诊断的准确性。
목적：응용Logistic회귀화ROC곡선탐토혈청암배항원( CEA)、린상세포암항원( SCC-Ag)화철단백( SF)검측재폐암림파결전이중적진단개치。방법분별검측100례수술전폐암환자혈청중삼충종류표지물수평,행수술학정림파결전이정황,통과Logistic회귀건립회귀모형,용ROC곡선분석삼항지표대폐암림파결전이적개치。결과림파결유전이조CEA、SCC-Ag적양성솔현저고우무전이조(P<0．01,P<0．05),이SF재량조간적양성솔비교차이무통계학의의(P >0．05)；건립회귀모형 Y =1/[1+EXP(1．584X1+0．935X2-0．425)],신변량Y적AUC고우삼충단일종류표지물적 AUC。결론종합운용 Logistic회귀화ROC곡선분석CEA、SCC-Ag화SF대폐암림파결전이적진단구유교고적개치,가제고기진단적준학성。
Objective To investigate the diagnostic value of serum carcinoembryonic antigen ( CEA) , squa-mous cell carcinoma antigen ( SCC-Ag) and ferritin ( SF) for lymph nodes metastasis in lung cancer. Methods The levels of CEA, SCC-Ag and SF were detected in 100 patients with lung cancer before surgery, and then they were giv-en surgery to determine lymph node metastasis. Logistic regression established by the regression model, and the diag-nostic value of the three tumor markers for lymph nodes metastasis was analyzed by ROC curve. Results The posi-tive rate of CEA and SCC-Ag was evidently higher in the metastasis group than in the non-metastasis group ( P<0. 01, P<0. 05), but there was no significant difference in SF between the two groups (P>0. 05). According to re-gression equation Y=1/[1+EXP(1. 584X1+0. 935X2-0. 425)], the AUC of variable Y was higher than any of the three tumor markers. Conclusion The combined detection of CEA, SCC-Ag and SF can improve the diagnostic ac-curacy of lymph nodes metastasis through logistic regression and ROC curve analysis.