CAJ | 학술논문

目的：观察和分析甘氨双唑钠( CMNa)对老年局部晚期非小细胞肺癌放疗的增敏疗效。方法选取80例老年局部晚期非小细胞肺癌患者作为研究对象,将其随机分为观察组和对照组,每组各40例。对照组应用单纯放疗治疗,观察组在放疗的基础上加用CMNa治疗。对于两组患者的近期疗效、生存时间分布及放射性食管炎、放射性肺炎、骨髓抑制等主要不良反应的发生情况进行观察和比较。结果观察组和对照组的临床有效率分别为77．5%和47．5%,两组之间的差异有显著性(χ2=7．680,P<0．05),而且观察组的近期疗效等级优于对照组,两组之间的差异有统计学意义(u=2．116,P<0．05)；两组患者的生存时间分布的差异无统计学意义(χ2=1．015,P>0．05)；两组患者的放射性肺炎、放射性食管炎和骨髓抑制等主要不良反应的发生率差异均无统计学意义(χ2=0．092、0．125、0．220、0．157、0．105,P>0．05)。结论老年局部晚期非小细胞肺癌患者的放疗中应用CMNa作为放疗增敏剂,可显著提高治疗的近期疗效,而且不会加重患者的放疗不良反应,但对于患者生存时间无显著的改善作用。
목적：관찰화분석감안쌍서납( CMNa)대노년국부만기비소세포폐암방료적증민료효。방법선취80례노년국부만기비소세포폐암환자작위연구대상,장기수궤분위관찰조화대조조,매조각40례。대조조응용단순방료치료,관찰조재방료적기출상가용CMNa치료。대우량조환자적근기료효、생존시간분포급방사성식관염、방사성폐염、골수억제등주요불량반응적발생정황진행관찰화비교。결과관찰조화대조조적림상유효솔분별위77．5%화47．5%,량조지간적차이유현저성(χ2=7．680,P<0．05),이차관찰조적근기료효등급우우대조조,량조지간적차이유통계학의의(u=2．116,P<0．05)；량조환자적생존시간분포적차이무통계학의의(χ2=1．015,P>0．05)；량조환자적방사성폐염、방사성식관염화골수억제등주요불량반응적발생솔차이균무통계학의의(χ2=0．092、0．125、0．220、0．157、0．105,P>0．05)。결론노년국부만기비소세포폐암환자적방료중응용CMNa작위방료증민제,가현저제고치료적근기료효,이차불회가중환자적방료불량반응,단대우환자생존시간무현저적개선작용。
Objective To observe and analyze the sensitization effect of metronidazole amino acidum natrium ( CMNa) in the radiotherapy for elderly patients with locally advanced non-small cell lung cancer. Methods 80 eld-erly patients with locally advanced non-small cell lung cancer were selected as the research objects and were randomly divided into the observation group and the control group, 40 cases in each group. The control group was treated with simple application of radiotherapy, while the observation group was treated with radiotherapy combined with CMNa treatment. The short-term efficacy, the survival time distribution and the occurrence of the major adverse reactions of radiation esophagitis, radiation pneumonitis and bone marrow suppression were observed and compared between the two groups. Results The clinical efficacy was 77. 5% and 47. 5% respectively in the observation group and the the control group (χ2 =7. 680, P<0. 05). The short-term curative effect was better in the observation group than in the the control group (u=2. 116, P<0. 05). There was no statistical significance on the survival time distribution of pa-tients between the two groups (χ2 =1. 015, P>0. 05). The occurrence of the major adverse reactions, such as radi-ation pneumonitis, radiation esophagitis and bone marrow suppression, showed no statistical significance (χ2 =0. 092, 0. 125, 0. 220, 0. 157, 0. 105, P>0. 05). Conclusion The application of CMNa as a radio-sensitizer can significantly improve the short-term efficacy of radiotherapy treatment, and will not increase the adverse reactions in the radiotherapy for elderly patients with locally advanced non small cell lung cancer, but it can not make significant improvement for the survival time of the patients.