CAJ | 학술논문

目的：探讨成人肠道淋巴样息肉病的临床及病理学特征。方法：应用光镜及免疫组织化学方法观察4例成人肠道淋巴样息肉病的组织学特点及免疫学表型，并复习相关文献。结果：4例中3例为男性，1例为女性，年龄分别为75、75、46及70岁。4例病例均因其他疾病切除末端回肠及回盲部时，偶然发现末端回肠多发息肉样隆起，直径0.1~0.5 cm。镜下见回肠粘膜淋巴组织显著增生，淋巴滤泡增生并形成息肉样小结节，淋巴滤泡的生发中心明显增大，围绕生发中心的套区境界清楚。免疫组织化学显示大部分呈滤泡样增生的淋巴细胞CD20强阳性表达，不表达Cyclin D1，生发中心细胞不表达Bcl-2。结论：成人淋巴样息肉病是一种罕见的良性病变，具有独特的临床病理特点，临床上易于同部分恶性肿瘤相混淆，诊断依靠病理组织学及部分辅助方法。
목적：탐토성인장도림파양식육병적림상급병이학특정。방법：응용광경급면역조직화학방법관찰4례성인장도림파양식육병적조직학특점급면역학표형，병복습상관문헌。결과：4례중3례위남성，1례위녀성，년령분별위75、75、46급70세。4례병례균인기타질병절제말단회장급회맹부시，우연발현말단회장다발식육양륭기，직경0.1~0.5 cm。경하견회장점막림파조직현저증생，림파려포증생병형성식육양소결절，림파려포적생발중심명현증대，위요생발중심적투구경계청초。면역조직화학현시대부분정려포양증생적림파세포CD20강양성표체，불표체Cyclin D1，생발중심세포불표체Bcl-2。결론：성인림파양식육병시일충한견적량성병변，구유독특적림상병리특점，림상상역우동부분악성종류상혼효，진단의고병리조직학급부분보조방법。
Objective:To explore the clinicopathological characteristics of intestinal lymphoid polyposis in adults. Methods:hTe histopathological features and immunophenotype of four cases of adult intestinal lymphoid polyposis were studied, relevant literatures were reviewed. Results:A total of 3 males and 1 female were studied, aged 75, 75, 46 and 70, respectively. In all four cases, identiifcation of the polyposis was incidental during the examination of resected of terminal ileum and ileocecal region due to other diseases. Gross findings were multiple polyps in the terminal ileum, measuring 0.1~0.5 cm in diameter. Microscopically, hyperplasia of mucosa-associated lymphoid tissue was noticed. The polyps were composed of closely aggregated lymphoid follicles. The follicles contained prominent germinal centers surrounded by a mantle of small lymphocytes. Immunohistochemical staining showed the follicles to be composed of CD20 (+) and Clyclin D1 (?) lymphocytes. Cells in germinal center did not express Bcl-2. Conclusion:Lymphoid polyposis is a rare benign tumor featuring unique clinicopathological characteristics. And the diagnosis relies on histopathological analysis and some ancillary markers.