临床与病理杂志
臨床與病理雜誌
림상여병리잡지
International Journal of Pathology and Clinical Medicine
2015年
5期
772-778
,共7页
邵云%许春伟%姜春婷%张俊%王怀涛%张博%邰艳红%李晓兵%江泽飞%吴世凯%宋三泰%黄焰%尉承泽
邵雲%許春偉%薑春婷%張俊%王懷濤%張博%邰豔紅%李曉兵%江澤飛%吳世凱%宋三泰%黃燄%尉承澤
소운%허춘위%강춘정%장준%왕부도%장박%태염홍%리효병%강택비%오세개%송삼태%황염%위승택
乳腺肿瘤%乳腺癌%临床病理分析
乳腺腫瘤%乳腺癌%臨床病理分析
유선종류%유선암%림상병리분석
breast neoplasm%breast cancer%clinicopathological analysis
目的：根据WHO(2003版)乳腺肿瘤分类标准，探讨军事医学科学院附属医院乳腺肿瘤的病理类型及分布特点。方法：收集2009年8月~2014年8月军事医学科学院附属医院诊治2392例乳腺肿瘤，复习其临床资料、HE及免疫组织化学切片。按WHO(2003版)分类标准进行病理诊断及分类。结果：2392例乳腺肿瘤中，绝大多数为女性患者(2382例)，占99.58%，男性10例(0.42%)。乳腺良性肿瘤982例(41.05%)，浸润性乳腺癌和原位癌1389例(58.07%)，乳腺恶性和交界性叶状肿瘤10例(0.42%)，淋巴瘤2例(0.08%)，转移性肿瘤9例(0.38%)。其中乳腺良性肿瘤中构成比居前5位分别为纤维腺瘤、导管内乳头状瘤、叶状肿瘤、脂肪瘤和管状腺瘤；纤维腺瘤患者发病高峰为20~40岁。浸润性乳腺癌中浸润性导管癌1112例(87.63%)，浸润性小叶癌37例(2.91%)，其他特殊类型癌120例(9.46%)。乳腺癌中以浸润性导管癌、浸润性小叶癌、基底细胞样乳腺癌、黏液癌最为多见。浸润性导管癌发病年龄以40~60岁居多。导管原位癌61例，导管内癌伴微浸润35例，小叶原位癌3例。Paget病10例(其中4例合并浸润性癌，4例合并导管内癌且3例伴微浸润)。乳腺癌中分子亚型分类Luminal A型693例(60.63%)；Luminal B型127例(11.11%)；Her-2过表达型130例(11.37%)；正常乳腺样(normal breast -like)型172例(15.05%)；Basal-like型21例(1.84%)。结论：对乳腺定期检查，提高早期诊断率，以期早期发现及时治疗。
目的：根據WHO(2003版)乳腺腫瘤分類標準，探討軍事醫學科學院附屬醫院乳腺腫瘤的病理類型及分佈特點。方法：收集2009年8月~2014年8月軍事醫學科學院附屬醫院診治2392例乳腺腫瘤，複習其臨床資料、HE及免疫組織化學切片。按WHO(2003版)分類標準進行病理診斷及分類。結果：2392例乳腺腫瘤中，絕大多數為女性患者(2382例)，佔99.58%，男性10例(0.42%)。乳腺良性腫瘤982例(41.05%)，浸潤性乳腺癌和原位癌1389例(58.07%)，乳腺噁性和交界性葉狀腫瘤10例(0.42%)，淋巴瘤2例(0.08%)，轉移性腫瘤9例(0.38%)。其中乳腺良性腫瘤中構成比居前5位分彆為纖維腺瘤、導管內乳頭狀瘤、葉狀腫瘤、脂肪瘤和管狀腺瘤；纖維腺瘤患者髮病高峰為20~40歲。浸潤性乳腺癌中浸潤性導管癌1112例(87.63%)，浸潤性小葉癌37例(2.91%)，其他特殊類型癌120例(9.46%)。乳腺癌中以浸潤性導管癌、浸潤性小葉癌、基底細胞樣乳腺癌、黏液癌最為多見。浸潤性導管癌髮病年齡以40~60歲居多。導管原位癌61例，導管內癌伴微浸潤35例，小葉原位癌3例。Paget病10例(其中4例閤併浸潤性癌，4例閤併導管內癌且3例伴微浸潤)。乳腺癌中分子亞型分類Luminal A型693例(60.63%)；Luminal B型127例(11.11%)；Her-2過錶達型130例(11.37%)；正常乳腺樣(normal breast -like)型172例(15.05%)；Basal-like型21例(1.84%)。結論：對乳腺定期檢查，提高早期診斷率，以期早期髮現及時治療。
목적：근거WHO(2003판)유선종류분류표준，탐토군사의학과학원부속의원유선종류적병리류형급분포특점。방법：수집2009년8월~2014년8월군사의학과학원부속의원진치2392례유선종류，복습기림상자료、HE급면역조직화학절편。안WHO(2003판)분류표준진행병리진단급분류。결과：2392례유선종류중，절대다수위녀성환자(2382례)，점99.58%，남성10례(0.42%)。유선량성종류982례(41.05%)，침윤성유선암화원위암1389례(58.07%)，유선악성화교계성협상종류10례(0.42%)，림파류2례(0.08%)，전이성종류9례(0.38%)。기중유선량성종류중구성비거전5위분별위섬유선류、도관내유두상류、협상종류、지방류화관상선류；섬유선류환자발병고봉위20~40세。침윤성유선암중침윤성도관암1112례(87.63%)，침윤성소협암37례(2.91%)，기타특수류형암120례(9.46%)。유선암중이침윤성도관암、침윤성소협암、기저세포양유선암、점액암최위다견。침윤성도관암발병년령이40~60세거다。도관원위암61례，도관내암반미침윤35례，소협원위암3례。Paget병10례(기중4례합병침윤성암，4례합병도관내암차3례반미침윤)。유선암중분자아형분류Luminal A형693례(60.63%)；Luminal B형127례(11.11%)；Her-2과표체형130례(11.37%)；정상유선양(normal breast -like)형172례(15.05%)；Basal-like형21례(1.84%)。결론：대유선정기검사，제고조기진단솔，이기조기발현급시치료。
Objective:To analyze clinicopathological features and observe the pathological type and distribution among breast neoplasms in Affliated Hospital of Academy of Military Medical Sciences, according to the World Health Organization criteria (2008). Methods:A retrospective analysis of 2,392 cases of breast neoplasms, which was made by authors, from August 2009 to August 2014. All the histopathological slides including HE slides and immunohistochemistry slides were re-examined and the medical records were reviewed. Results:Among the 2,392 cases, most patients were female (2,382, 99.58%) and rare patients were male (10, 0.42%), 982 cases were benign tumor (41.05%), 1,389 were breast cancer or carcinoma in situ (58.07%), 10 were malignant or borderline phyllodes tumors (0.42%), 2 were lymphoma(0.08%), and 9 were metastase tumor (0.38%). Among the benign tumors, ifbroadenoma, intraductal papilloma, benign phyllodes tumor, lipoma and tubular adenoma were more common in turn, the peak of fibroadenoma occurs in patients aged 20~40, while most of breast cancer were invasive ductal carcinoma 1,112 cases (87.63%), then lobular carcinoma (37, 2.91%), other special types cancer (120, 9.46%). Among breast cancer, infiltrating ductal carcinoma, invasive lobular carcinoma, basal-like breast cancer, mucinous carcinoma were more common in turn. hTe peak of invasive ductal carcinoma occurs in patients aged 40~60. Among breast cancer 693 cases were Luminal A type, 127 were Luminal B type, 130 were Her-2 type, 172 were normal breast-like type, and 21 were basal-like type. Conclusion:It is important to promote the early diagnosis of breast carcinoma by periodic inspection for early treatment breast neoplasms.
