CAJ | 학술논문

目的：探讨噻托溴铵对慢性阻塞性肺疾病（COPD）的疗效，观察其对血清中C反应蛋白（CRP）、白细胞介素-6（IL-6）和白细胞介素-12（IL-12）的影响。方法收集我院治疗的114例COPD的患者，随机分为观察组和对照组，观察组(57例)在常规治疗基础上加用噻托溴铵治疗，对照组（57例）在常规治疗基础上加用氨茶碱。观察治疗的效果及对血清中CRP、IL-6和IL-12表达的影响。结果观察组的疗效明显高于对照组，观察组治疗后血清中CRP、IL-6和IL-12的下降值明显高于对照组。结论噻托溴铵对COPD的疗效明显，且对血清中CRP、IL-6和IL-12的表达有明显下调作用，临床中可以积极应用。
목적：탐토새탁추안대만성조새성폐질병（COPD）적료효，관찰기대혈청중C반응단백（CRP）、백세포개소-6（IL-6）화백세포개소-12（IL-12）적영향。방법수집아원치료적114례COPD적환자，수궤분위관찰조화대조조，관찰조(57례)재상규치료기출상가용새탁추안치료，대조조（57례）재상규치료기출상가용안다감。관찰치료적효과급대혈청중CRP、IL-6화IL-12표체적영향。결과관찰조적료효명현고우대조조，관찰조치료후혈청중CRP、IL-6화IL-12적하강치명현고우대조조。결론새탁추안대COPD적료효명현，차대혈청중CRP、IL-6화IL-12적표체유명현하조작용，림상중가이적겁응용。
Objective To observe the curative effect, CRP, IL-6 and IL-12 change by Tiotropium Bromide in patients with COPD, for accumulating the clinical experience, directing the clinical work. Methods 114 patients were divided into two groups. The control group (57 cases) applied routine treatment and Aminophylline, the observation group (57 cases) applied routine treatment and Tiotropium Bromide. Efficacy and changes of CRP, IL-6 and IL-12 were observed in two groups after treatment. Results The effect was obviously better in the observation group than in the control group. The change value of CRP, IL-6 and IL-12 were obviously higher in the observation group after treatment. Conclusion Tiotropium Bromide can improve effect, regulate the expressions of CRP, IL-6 and IL-12 in patients with COPD, is worthy of being recommended in clinical treatment.