CAJ | 학술논문

目的：研究含锶羟基磷灰石对骨质疏松症大鼠的影响。方法制备羟基磷灰石（HA）和10％含锶羟基磷灰石（10％SrHA，即HA中Sr与Ca的摩尔比例为1：9）种植体，以扫描电镜（SEM）、能量色散X射线能谱仪（EDX）、X射线衍射（XRD）检测材料表面形貌特征。实验中将20只雌性SD大鼠均行双侧卵巢切除术，12周后将所有动物随机平均分为两组，并分别在大鼠右侧股骨远端植入羟基磷灰石（HA）种植体和10％含锶羟基磷灰石（10％SrHA）种植体。植入术后8周，收集标本行显微CT（ micro-CT）和组织学分析。结果实验所得数据采用SPSS17.0软件进行统计学分析。在micro-CT检验的结果中，相比于HA种植体组，10％SrHA种植体组的相对骨体积提高了42.6％，骨结合率提高了47.1％，平均骨小梁数量提高了27.3％，平均骨小梁厚度提高了31.5％，平均骨小梁连接密度提高了37.4％，而平均骨小梁间距降低了20.1％。在组织学检验结果中，10％SrHA组的相对骨面积密度提高了47.6％。结论以HA种植体作为对照，10％SrHA种植体可以提高骨密度和骨结合率，同时改善种植体周的骨小梁微结构。
목적：연구함송간기린회석대골질소송증대서적영향。방법제비간기린회석（HA）화10％함송간기린회석（10％SrHA，즉HA중Sr여Ca적마이비례위1：9）충식체，이소묘전경（SEM）、능량색산X사선능보의（EDX）、X사선연사（XRD）검측재료표면형모특정。실험중장20지자성SD대서균행쌍측란소절제술，12주후장소유동물수궤평균분위량조，병분별재대서우측고골원단식입간기린회석（HA）충식체화10％함송간기린회석（10％SrHA）충식체。식입술후8주，수집표본행현미CT（ micro-CT）화조직학분석。결과실험소득수거채용SPSS17.0연건진행통계학분석。재micro-CT검험적결과중，상비우HA충식체조，10％SrHA충식체조적상대골체적제고료42.6％，골결합솔제고료47.1％，평균골소량수량제고료27.3％，평균골소량후도제고료31.5％，평균골소량련접밀도제고료37.4％，이평균골소량간거강저료20.1％。재조직학검험결과중，10％SrHA조적상대골면적밀도제고료47.6％。결론이HA충식체작위대조，10％SrHA충식체가이제고골밀도화골결합솔，동시개선충식체주적골소량미결구。
Objective To study the effect of strontium-containing hydroxyapatite on osteoporotic rats.Methods Hydroxyapatite ( HA) and 10% strontium containing hydroxyapatite ( 10% SrHA, the mole ratio of Sr and Ca 1∶9 ) implants were prepared. Scanning electron microscopy ( SEM) , energy dispersive microanalysis ( EDX) , and X-ray diffraction ( XRD) were used to study the surface feature of the implants.Twenty female SD rats were subjected to bilateral ovariectomy.After 12 weeks the animals were randomly divided into 2 groups of 10 rats each.HA or 10%SrHA were implanted in the right side of the distal femur in rats of each group respectively.8 weeks after implantation, specimens for microscopic ( micro-CT ) analysis and histology were collected. Results Statistical analysis was performed using SPSS17.0 software.Micro-CT test results showed that compared to HA group, the relative bone volume increased by 42.6%, the bone-to-implant contact increased by 47.1%, the mean trabecular bone volume increased by 27.3%, the mean trabecular thickness increased by 31.5%, the mean trabecular connectivity density increased by 37.4%, and the mean trabecular bone spacing reduced by 20.1%in the 10%SrHA group.The bone area density in the 10%SrHA group increased by 47.6%compared to HA group.Conclusion With HA implants as controls, 10%SrHA implants increase the bone mineral density and bone-to-implant contact, and improve the trabecular bone micro structure around the implants.