中华内科杂志
中華內科雜誌
중화내과잡지
CHINESE JOURNAL OF INTERNAL MEDICINE
2015年
6期
517-520
,共4页
陈长喜%杜娟%徐益敏%陈晓斐%余荣%毛玉山%郭传勇
陳長喜%杜娟%徐益敏%陳曉斐%餘榮%毛玉山%郭傳勇
진장희%두연%서익민%진효비%여영%모옥산%곽전용
流行病学%中年人%老年人%非酒精性脂肪性肝病%糖化血红蛋白
流行病學%中年人%老年人%非酒精性脂肪性肝病%糖化血紅蛋白
류행병학%중년인%노년인%비주정성지방성간병%당화혈홍단백
Epidemiology%Middle aged%Aged%Non-alcoholic fatty liver disease%Glycosylated hemoglobin
目的 探讨中老年人群中非酒精性脂肪性肝病(NAFLD)与糖化血红蛋白(HbA1c)的关系.方法 调查符合入选条件的4 127名年龄45岁及以上的宁波市某石化企业在职和退休员工,测定其腰围、BMI、血压、空腹血糖、血脂谱、γ-谷氨酰转肽酶(γ-GT)、HbA1c,并行上腹部B超检查.按HbA1c水平的四分位数进行分层,分为Q1～Q4组(HbA1c水平分别为:Q1组≤5.2％,Q2组＞5.2％～5.4％,Q3组＞5.4％～5.6％,Q4组＞5.6％),分析各组的NAFLD患病率情况及临床特征,并采用logistic多元回归进行NAFLD患病危险因素分析.结果 NAFLD患病率27.2％,其中男性31.9％、女性21.0％,男性患病率较女性高(P ＜0.001);Q1、Q2、Q3、Q4组NAFLD的患病率分别为18.5％(178/961)、22.8％(185/812)、25.6％(280/1 095)、38.1％(480/1 259),随着HbA1c水平的增高NAFLD的患病率逐渐升高;1 123例NAFLD患者年龄、收缩压、TC、LDL-C、空腹血糖均随着HbA1c水平的升高而递增;logistic多元回归分析显示高HbA1c水平为NAFLD患病的危险因素(OR=1.67,95％CI 1.15 ～2.43,P=0.007).结论 HbA1c是NAFLD患病的危险因素,且两者都与血脂代谢紊乱联系紧密.
目的 探討中老年人群中非酒精性脂肪性肝病(NAFLD)與糖化血紅蛋白(HbA1c)的關繫.方法 調查符閤入選條件的4 127名年齡45歲及以上的寧波市某石化企業在職和退休員工,測定其腰圍、BMI、血壓、空腹血糖、血脂譜、γ-穀氨酰轉肽酶(γ-GT)、HbA1c,併行上腹部B超檢查.按HbA1c水平的四分位數進行分層,分為Q1～Q4組(HbA1c水平分彆為:Q1組≤5.2％,Q2組＞5.2％～5.4％,Q3組＞5.4％～5.6％,Q4組＞5.6％),分析各組的NAFLD患病率情況及臨床特徵,併採用logistic多元迴歸進行NAFLD患病危險因素分析.結果 NAFLD患病率27.2％,其中男性31.9％、女性21.0％,男性患病率較女性高(P ＜0.001);Q1、Q2、Q3、Q4組NAFLD的患病率分彆為18.5％(178/961)、22.8％(185/812)、25.6％(280/1 095)、38.1％(480/1 259),隨著HbA1c水平的增高NAFLD的患病率逐漸升高;1 123例NAFLD患者年齡、收縮壓、TC、LDL-C、空腹血糖均隨著HbA1c水平的升高而遞增;logistic多元迴歸分析顯示高HbA1c水平為NAFLD患病的危險因素(OR=1.67,95％CI 1.15 ～2.43,P=0.007).結論 HbA1c是NAFLD患病的危險因素,且兩者都與血脂代謝紊亂聯繫緊密.
목적 탐토중노년인군중비주정성지방성간병(NAFLD)여당화혈홍단백(HbA1c)적관계.방법 조사부합입선조건적4 127명년령45세급이상적저파시모석화기업재직화퇴휴원공,측정기요위、BMI、혈압、공복혈당、혈지보、γ-곡안선전태매(γ-GT)、HbA1c,병행상복부B초검사.안HbA1c수평적사분위수진행분층,분위Q1～Q4조(HbA1c수평분별위:Q1조≤5.2％,Q2조＞5.2％～5.4％,Q3조＞5.4％～5.6％,Q4조＞5.6％),분석각조적NAFLD환병솔정황급림상특정,병채용logistic다원회귀진행NAFLD환병위험인소분석.결과 NAFLD환병솔27.2％,기중남성31.9％、녀성21.0％,남성환병솔교녀성고(P ＜0.001);Q1、Q2、Q3、Q4조NAFLD적환병솔분별위18.5％(178/961)、22.8％(185/812)、25.6％(280/1 095)、38.1％(480/1 259),수착HbA1c수평적증고NAFLD적환병솔축점승고;1 123례NAFLD환자년령、수축압、TC、LDL-C、공복혈당균수착HbA1c수평적승고이체증;logistic다원회귀분석현시고HbA1c수평위NAFLD환병적위험인소(OR=1.67,95％CI 1.15 ～2.43,P=0.007).결론 HbA1c시NAFLD환병적위험인소,차량자도여혈지대사문란련계긴밀.
Objective To study the correlation between non-alcoholic fatty liver disease (NAFLD)and glycosylated hemoglobin (HbA1 c) in middle-aged and aged population.Methods A total of 4 127 inservice workers and retirees aged 45 years old or above from one petrochemical enterprise in Ningbo were enrolled in our study.The waistline,body mass index,blood pressure,fasting blood-glucose,blood lipid profile,glutamyltranspeptidase,HbA1c and epigastrium B ultrasound were investigated.According to the quartile of HbA1c level,participants were divided into four groups,namely,Q1 group ≤5.2％,Q2 group ＞ 5.2％-5.4％,Q3 ＞ 5.4％-5.6％ and Q4 group ＞ 5.6％.The prevalence of NAFLD and clinical characteristics of each group were analyzed.Logistic regression was used to predict independent risk factors of NAFLD.Results The morbidity of NAFLD was 27.2％ with 31.9％ in male and 21％ in female,which was significantly higher in men.In Q1,Q2,Q3 and Q4 group,the prevalence of NAFLD were 18.5％ (178/961),22.8％ (185/812),25.6％ (280/1 095),38.1％ (480/1 259) respectively.With the increase of HbA1 c level,the morbidity of NAFLD increased synchronously.The age,systolic pressure,total cholesterol,low densitylipoprotein cholesterin and fasting blood-glucose were all elevated according to the increase of HbA1 c in 1 123 NAFLD patients.Multi-factor logistic regression analysis indicated that high HbAlc level was the risk factor of NAFLD (OR =1.67,95％ CI 1.15-2.43,P =0.007).Conclusion HbA1c is an independent risk factor of NAFLD and both of these are closely related to blood lipid metabolism disorder.
