CAJ | 학술논문

丝氨酸蛋白酶抑制剂B9(Serpin B9)是蛋白酶抑制剂超家族成员,包括人丝氨酸蛋白酶抑制剂(PI-9)及鼠丝氨酸蛋白酶抑制剂同源蛋白(SPI-6),是主要针对颗粒蛋白酶B(GrB)的内源性蛋白酶抑制剂.Serpin B9的调节在T淋巴细胞、树突状细胞、自然杀伤细胞、中性粒细胞、间充质干细胞、肿瘤细胞有抑制凋亡、维持细胞平衡、调节免疫反应、增强DNA疫苗能力等功能.研究Serpin B9的作用机理,将有利于相关免疫疾病发生机制的探索,并为临床干细胞治疗、抗肿瘤治疗等提供新的理论依据.
사안산단백매억제제B9(Serpin B9)시단백매억제제초가족성원,포괄인사안산단백매억제제(PI-9)급서사안산단백매억제제동원단백(SPI-6),시주요침대과립단백매B(GrB)적내원성단백매억제제.Serpin B9적조절재T림파세포、수돌상세포、자연살상세포、중성립세포、간충질간세포、종류세포유억제조망、유지세포평형、조절면역반응、증강DNA역묘능력등공능.연구Serpin B9적작용궤리,장유리우상관면역질병발생궤제적탐색,병위림상간세포치료、항종류치료등제공신적이론의거.
Serine proteinase inhibitor B9 (Serpin B9),one member of the protease inhibitor superfamily including human serine proteinase inhibitor 9 (PI-9) and rat serine proteinase inhibitor homologous protein SPI-6,is an endogenous protease inhibitor mainly against GrB.Serpin B9 regulate apoptosis,immune reaction,DNA vaccines' abilities in T lymphocytes,dendritic cells,natural killer cells,neutrophils,mesenchymal stem cells and tumor cells.Study on the function of Serpin B9 could not only facilitate further exploration of the mechanism of immune related diseases,but also provide new theoretical basis for the treatment of tumor and the clinical applicution of stem cells.