CAJ | 학술논문

在肺移植缺血再灌注的过程中,从供体肺的保存到移植后再灌注造成严重的移植损伤是造成肺移植术后高死亡率的主要原因之一.因肺容易造成病理损伤,所以任何造成肺泡血氧交换和肺血管循环障碍均会导致肺缺血,在长达几小时的肺移植过程中,由于肺通气血流障碍而造成严重的肺缺血是不可避免的.而单个器官血液供需失衡会导致严重的组织缺氧和微血管功能障碍,后续再灌注又进一步增强了激活的固有免疫反应和适应性免疫反应以及细胞死亡程序,这些途径均对肺移植病人的预后造成不良影响.因而研究和探讨肺移植缺血再灌注损伤(IRI)免疫途径及其保护措施具有重要的现实意义.
재폐이식결혈재관주적과정중,종공체폐적보존도이식후재관주조성엄중적이식손상시조성폐이식술후고사망솔적주요원인지일.인폐용역조성병리손상,소이임하조성폐포혈양교환화폐혈관순배장애균회도치폐결혈,재장체궤소시적폐이식과정중,유우폐통기혈류장애이조성엄중적폐결혈시불가피면적.이단개기관혈액공수실형회도치엄중적조직결양화미혈관공능장애,후속재관주우진일보증강료격활적고유면역반응화괄응성면역반응이급세포사망정서,저사도경균대폐이식병인적예후조성불량영향.인이연구화탐토폐이식결혈재관주손상(IRI)면역도경급기보호조시구유중요적현실의의.
In lung transplantation,ischemia-reperfusion injury (IRI) due to preservation and subsequent reperfusion causes significant transplant damage.It is one of the main reasons for high mortality after lung transplantation.Lung is vulnerable to pathological damage.Condition impairing the alveolar oxygenation or pulmonary blood flow will finally result in lung ischemia.The rigorous anoxic ischemia due to the interruption of both pulmonary bloodstream and ventilation for up to several hours are inevitable in lung transplantation.An imbalance in metabolic supply and demand within the ischemic organ results in profound tissue hypoxia and microvascular dysfunction.Subsequent reperfusion further enhances the activation of innate and adaptive immune responses and cell death program.Thus to explore the immune pathways involved in lung transplant ischemiareperfusion injury and its protection has an important practical significance.