国际免疫学杂志
國際免疫學雜誌
국제면역학잡지
INTERNATIONAL JOURNAL OF IMMUNOLOGY
2015年
3期
276-279
,共4页
辅助性T细胞9%白细胞介素-9%CD4+T细胞
輔助性T細胞9%白細胞介素-9%CD4+T細胞
보조성T세포9%백세포개소-9%CD4+T세포
Th9%Interleukin-9%CD4+T cells
CD4+T细胞在免疫应答反应中发挥关键作用,CD4+T细胞根据其分泌的细胞因子的不同分为多种细胞亚群.其中辅助性T细胞9(Th9)细胞是最近发现的一种新型的CD4+效应T细胞,该细胞由Na(i)ve CD4+T细胞分化而来,可分泌特征性的细胞因子白细胞介素(IL)-9.Th9细胞的发育和分化具有独立的调节机制,其在过敏性炎症、自身免疫病和抗肿瘤免疫中发挥着重要作用.然而,Th9细胞在免疫应答反应中的调控,与其它CD4+T细胞亚群的相互作用及在疾病中的效应作用等问题仍需深入研究.
CD4+T細胞在免疫應答反應中髮揮關鍵作用,CD4+T細胞根據其分泌的細胞因子的不同分為多種細胞亞群.其中輔助性T細胞9(Th9)細胞是最近髮現的一種新型的CD4+效應T細胞,該細胞由Na(i)ve CD4+T細胞分化而來,可分泌特徵性的細胞因子白細胞介素(IL)-9.Th9細胞的髮育和分化具有獨立的調節機製,其在過敏性炎癥、自身免疫病和抗腫瘤免疫中髮揮著重要作用.然而,Th9細胞在免疫應答反應中的調控,與其它CD4+T細胞亞群的相互作用及在疾病中的效應作用等問題仍需深入研究.
CD4+T세포재면역응답반응중발휘관건작용,CD4+T세포근거기분비적세포인자적불동분위다충세포아군.기중보조성T세포9(Th9)세포시최근발현적일충신형적CD4+효응T세포,해세포유Na(i)ve CD4+T세포분화이래,가분비특정성적세포인자백세포개소(IL)-9.Th9세포적발육화분화구유독립적조절궤제,기재과민성염증、자신면역병화항종류면역중발휘착중요작용.연이,Th9세포재면역응답반응중적조공,여기타CD4+T세포아군적상호작용급재질병중적효응작용등문제잉수심입연구.
CD4+T cells play an important role in immune response.Currently,several CD4+T cell subsets have been identified based on their cytokine production.Recently,a new subset of the CD4+T cell (Th9) cells,has been defined.Th9 cells are derived from Na(i)ve CD4+T cells,and they produce characteristic IL-9.The development and differentiation of Th9 cells have independent regulatory mechanisms.Th9 cells play a significant role in allergic inflammation,autoimmune diseases,and anti-tumor immunity.However,there are many questions need further study,such as the regulation of immune responses mediated by Th9 cells,the interaction among Th9 cells and other CD4+T cells subsets,and the role of Th9 cells in diseases.
