CAJ | 학술논문

多发性硬化(MS)是中枢神经系统慢性炎症性脱髓鞘性疾病,其发病机制与免疫调节功能异常密切相关,各种细胞因子对MS易感性的研究已经被证实,慢性炎症反应通过炎症反应细胞因子如白细胞介素10(IL-10)、肿瘤坏死因子β(TNF-β)、γ-干扰素(IFN-γ)等发挥免疫效应.因此研究与MS相关的细胞因子的变化对于MS发病机制的探索有着重要意义.
다발성경화(MS)시중추신경계통만성염증성탈수초성질병,기발병궤제여면역조절공능이상밀절상관,각충세포인자대MS역감성적연구이경피증실,만성염증반응통과염증반응세포인자여백세포개소10(IL-10)、종류배사인자β(TNF-β)、γ-간우소(IFN-γ)등발휘면역효응.인차연구여MS상관적세포인자적변화대우MS발병궤제적탐색유착중요의의.
Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of central nervous system.Its pathogenesis is closely related to the abnormality of immuoregulation.The effect of various cytokines on the susceptibility of patients to MS has been confirmed.Chronic inflammation plays important roles through inflammatory cytokines such as interleukin-10 (IL-10),tumor necrosis factor-β (TNF-β),and interferon-γ (IFN-γ).Researches on cytokines' changes in MS are of great significance to explore the pathogenesis of MS.