CAJ | 학술논문

哺乳动物核因子-κB (NF-κB)家族由c-Rel、RelA(p65)、RelB、NF-κB1(p50/p105)以及NF-κB2(p52/p100)五名成员组成.相比于其它家族成员广泛表达于机体的各种细胞,c-Rel主要在活化的淋巴细胞和单核细胞中表达,并与多种免疫细胞的分化以及炎性因子的表达密切相关,从而在自身免疫病的病理过程中发挥着重要作用.
포유동물핵인자-κB (NF-κB)가족유c-Rel、RelA(p65)、RelB、NF-κB1(p50/p105)이급NF-κB2(p52/p100)오명성원조성.상비우기타가족성원엄범표체우궤체적각충세포,c-Rel주요재활화적림파세포화단핵세포중표체,병여다충면역세포적분화이급염성인자적표체밀절상관,종이재자신면역병적병리과정중발휘착중요작용.
The mammalian nuclear factor-kappaB (NF-κB) family consists of five members:c-Rel、RelA(p65) 、RelB,NF-κB1 (p50/p105) and NF-κB2(p52/p100),each of which is endowed with a distinct set of function not shared by other members,although each member may also perform additional functions common to the family.Unlike other members of the NF-κB family that are ubiquitously expressed,c-Rel is preferentially expressed by inflammatory cells and is used to directly control the expression of multiple inflammatory genes that mediate autoimmune diseases such as autoimmune encephalomyelitis and psoriasis,and its alteration is associated with an increased risk for human inflammatory diseases.Thus c-Rel is not only a pathogenic gene but also a susceptibility gene for autoimmune diseases.