CAJ | 학술논문

肿瘤具有免疫原性,在人类肿瘤组织中可发现大量肿瘤浸润性淋巴细胞;大多数肿瘤患者在接受主动免疫治疗后可以检测到参与应答反应的肿瘤抗原特异性T细胞.但是主动免疫治疗并未给患者带来显著的临床疗效,究其原因发现肿瘤微环境中的免疫抑制状态削弱了效应细胞的杀瘤活性.因此深入研究肿瘤与免疫系统的相互作用将有助于提高临床生物治疗的疗效.
종류구유면역원성,재인류종류조직중가발현대량종류침윤성림파세포;대다수종류환자재접수주동면역치료후가이검측도삼여응답반응적종류항원특이성T세포.단시주동면역치료병미급환자대래현저적림상료효,구기원인발현종류미배경중적면역억제상태삭약료효응세포적살류활성.인차심입연구종류여면역계통적상호작용장유조우제고림상생물치료적료효.
Tumor infiltrating lymphocytes can be found in human tumor tissues.Although after active immune therapy,tumor-reactive T cells could be detected in most patients' peripheral blood,patients often get little clinical benefit.Now it is believed that tumor microenvironment suppresses immune response and causes tumor immune escape.Here we review the mechanism of tumor immune escape and tumor immunotherapy strategies.