CAJ | 학술논문

骨骼是除肝脏和肺脏外恶性肿瘤最常见的转移部位.骨转移(bone metastasis)被认为是临床严重的并发症之一.有文献显示超过70％的各类癌症晚期患者会发生骨转移,骨转移会诱发骨痛、病理性骨折、脊髓压迫和高钙血症等,因其导致的死亡率和致残率分别为20％和45％.在保证治疗原发肿瘤的基础上,怎样最大限度的治疗骨转移瘤和诱发最小的副作用是目前医学界研究的热点.靶向给药体系(targeted drug delivery system)包括双磷酸盐类、四环素类、单克隆抗体、聚乙烯亚胺等,它能有效的抑制骨转移,旨在为治疗骨转移提供更有效的策略.
골격시제간장화폐장외악성종류최상견적전이부위.골전이(bone metastasis)피인위시림상엄중적병발증지일.유문헌현시초과70％적각유암증만기환자회발생골전이,골전이회유발골통、병이성골절、척수압박화고개혈증등,인기도치적사망솔화치잔솔분별위20％화45％.재보증치료원발종류적기출상,즘양최대한도적치료골전이류화유발최소적부작용시목전의학계연구적열점.파향급약체계(targeted drug delivery system)포괄쌍린산염류、사배소류、단극륭항체、취을희아알등,타능유효적억제골전이,지재위치료골전이제공경유효적책략.
Bones were the most frequent cancer metastatic sites except liver and lung.Bone metastasis is consider one of the serious complications.Several reports showed that more than 70％ end-stage cancer patients might have bone metastasis.Bone metastasis could develop pain,pathological fractures,spinal cord compression and hypercalcenia et al.The mortality and disability rate induced by bone metastasis were 20 and 45％,respectively.How to treat bone metastasis and induce the minimal side effects is hot topic of medical research.Targeted drug delivery system contains bisphosphonates,tetracyclines,monoclonal antibodies and polyethylenimine.It could efficiently control bone metastasis and provide resultful therapeutic strategies for treatment of bone metastasis.