CAJ | 학술논문

目的：通过检测慢性心力衰竭患者血 N 端 B 型脑钠肽前体水平，探讨其与心力衰竭患者预后的相关性。方法选择2010年10月-2013年5月辽宁中医药大学附属四院急诊病房收治的600例心力衰竭患者作为治疗组，我院门诊健康体检者60例作为对照组，测定血 N 端 B 型脑钠肽前体（NT - proBNP）水平，将治疗组根据心功能不全级别分为 NYHAⅠ、Ⅱ、Ⅲ、Ⅳ组，并用超声多普勒测定左室射血分数（LVEF 值），研究血 N 端 B 型脑钠肽前体与心力衰竭患者预后的相关性。结果血NT - proBNP 水平与患者病情好转情况成负相关；血 NT - proBNP 水平升高，6个月病死率越高；随着患者的年龄增长，血 NT - proBNP 水平逐渐升高。结论血清 NT - proBNP 水平升高，提示心力衰竭患者的预后差，病死率高。
목적：통과검측만성심력쇠갈환자혈 N 단 B 형뇌납태전체수평，탐토기여심력쇠갈환자예후적상관성。방법선택2010년10월-2013년5월료녕중의약대학부속사원급진병방수치적600례심력쇠갈환자작위치료조，아원문진건강체검자60례작위대조조，측정혈 N 단 B 형뇌납태전체（NT - proBNP）수평，장치료조근거심공능불전급별분위 NYHAⅠ、Ⅱ、Ⅲ、Ⅳ조，병용초성다보륵측정좌실사혈분수（LVEF 치），연구혈 N 단 B 형뇌납태전체여심력쇠갈환자예후적상관성。결과혈NT - proBNP 수평여환자병정호전정황성부상관；혈 NT - proBNP 수평승고，6개월병사솔월고；수착환자적년령증장，혈 NT - proBNP 수평축점승고。결론혈청 NT - proBNP 수평승고，제시심력쇠갈환자적예후차，병사솔고。
Objective By the detection of blood b - type brain natriuretic peptide precursor level N end of patients with chronic heart failure to explore its correlation with the prognosis of patients with heart failure. Methods Six hundred patients with heart failure admitted to the Fourth Hospital of Liaoning Univer-sity of Traditional Chinese Medicine from October 2010 to May 2013 were taKen into treatment group and 60 cases of outpatient health checK - up in our hospital were taKen as the control. Blood NT - proBNP level was measured,and patients in the treatment group were divided into the subgroups of NYHA Ⅰ,Ⅱ,Ⅲ,Ⅳ group according to the level of cardiac insufficiency. The blood b - type brain natriuretic peptide precursor N end correlation with the prognosis of patients with heart failure were studied with the determination of ultrasonic doppler left ventricular ejection fraction(LVEF). Results There was negative correlation between the blood level of NT - proBNP and patients getting better;along with the increase of NT - proBNP blood levels,the mortality after 6 months was the highest;along with the increase of patient's age,blood NT - proBNP level in-creased. Conclusion The increase of serum level of NT - proBNP indicates poor prognosis of heart failure and high mortality.