CAJ | 학술논문

目的：了解深圳市福田区人民医院（以下简称“我院”）药品不良反应（ ADR）的发生特点及原因，促进临床合理用药。方法：对2012年1月—2013年12月在我院接受药物治疗发生不良反应的150例患者的临床资料进行统计分析。结果：150例发生ADR的患者中，男性35例（占23.3％），女性115例（占76.7％）；年龄1～78岁，平均（48±3.9）岁；表现为过敏反应35例（占23.3％），特异性反应52例（占34.7％），毒性反应17例（占11.3％），二重感染46例（占30.7％）；引起ADR的给药途径以静脉给药为主，共114例，占76.0％；中成药引起的ADR最多，为65例，占43.3％。结论：应加强用药管理、提高合理用药水平，从不同的因素实施针对性的管理，以减少ADR的发生。
목적：료해심수시복전구인민의원（이하간칭“아원”）약품불량반응（ ADR）적발생특점급원인，촉진림상합리용약。방법：대2012년1월—2013년12월재아원접수약물치료발생불량반응적150례환자적림상자료진행통계분석。결과：150례발생ADR적환자중，남성35례（점23.3％），녀성115례（점76.7％）；년령1～78세，평균（48±3.9）세；표현위과민반응35례（점23.3％），특이성반응52례（점34.7％），독성반응17례（점11.3％），이중감염46례（점30.7％）；인기ADR적급약도경이정맥급약위주，공114례，점76.0％；중성약인기적ADR최다，위65례，점43.3％。결론：응가강용약관리、제고합리용약수평，종불동적인소실시침대성적관리，이감소ADR적발생。
OBJECTIVE:To investigate the characteristics and causes of the adverse drug reactions (ADRs) in Shenzhen Futian District People's Hospital (hereinafter referred to as “our hospital”) for clinical reference of rational use of drugs. METHODS:The clinical data of 150 ADR cases collected in our hospital from Jan.2012 to Dec.2013 were statistically analyzed.RESULTS:The ADR (150 cases) occurred more often in males than in males (35 cases/23.3%vs.115 cases/76.7%) and in patients aged 1-78 years (mean age of 48 ±3.9 years), manifested mostly as allergic reaction (35 cases/23.3%), specific reaction (52 cases/34.7%), toxic reaction (17 cases /11.3%) and superinfection (46 cases/30.7%), induced mainly by drugs administered intravenously ( 114 cases/76.0%) and prediomiantly by Chinese patent drugs (65cases/43.3%).CONCLUSIONS:It is important to tigten control on drug use, enhance rational use of drugs, carry out targeted management aimed at different factors so as to reduce the incidence of ADRs.