中国医院用药评价与分析
中國醫院用藥評價與分析
중국의원용약평개여분석
EVALUATION AND ANAL YSIS OF DRUG-USE IN HOSPITALS OF CHINA
2015年
5期
662-663
,共2页
辛伐他汀%高脂血症%临床疗效
辛伐他汀%高脂血癥%臨床療效
신벌타정%고지혈증%림상료효
Imvastatin%Hyperlipidemia%Clinical efficacy
目的:探讨不同剂量辛伐他汀治疗老年高脂血症的可行性。方法:选取2012年5月—2014年5月解放军白求恩国际和平医院收治的老年高脂血症患者共72例,以随机数字表法将其等分成2组,对照组应用小剂量辛伐他汀(20 mg/d)治疗,观察组给予高剂量辛伐他汀(40 mg/d)用药,研究2组的临床治疗效果和用药安全性,同时评估其施治前后的血脂改善情况。结果:观察组治疗后的临床总有效率为94.4%显著高于对照组的80.6%( P<0.05)。治疗前,2组患者的总胆固醇、三酰甘油、低密度脂蛋白胆固醇和高密度脂蛋白胆固醇等指标值相似(P>0.05),经治疗后均改善,且观察组较对照组改善更显著(P<0.05)。在治疗成本上,观察组较对照组高,差异有统计学意义( P<0.05)。结论:对老年高脂血症患者实施高剂量辛伐他汀进行治疗,虽然治疗成本较高,但疗效更显著,对血脂水平改善效果更理想,且安全性佳,值得在临床普及推广。
目的:探討不同劑量辛伐他汀治療老年高脂血癥的可行性。方法:選取2012年5月—2014年5月解放軍白求恩國際和平醫院收治的老年高脂血癥患者共72例,以隨機數字錶法將其等分成2組,對照組應用小劑量辛伐他汀(20 mg/d)治療,觀察組給予高劑量辛伐他汀(40 mg/d)用藥,研究2組的臨床治療效果和用藥安全性,同時評估其施治前後的血脂改善情況。結果:觀察組治療後的臨床總有效率為94.4%顯著高于對照組的80.6%( P<0.05)。治療前,2組患者的總膽固醇、三酰甘油、低密度脂蛋白膽固醇和高密度脂蛋白膽固醇等指標值相似(P>0.05),經治療後均改善,且觀察組較對照組改善更顯著(P<0.05)。在治療成本上,觀察組較對照組高,差異有統計學意義( P<0.05)。結論:對老年高脂血癥患者實施高劑量辛伐他汀進行治療,雖然治療成本較高,但療效更顯著,對血脂水平改善效果更理想,且安全性佳,值得在臨床普及推廣。
목적:탐토불동제량신벌타정치료노년고지혈증적가행성。방법:선취2012년5월—2014년5월해방군백구은국제화평의원수치적노년고지혈증환자공72례,이수궤수자표법장기등분성2조,대조조응용소제량신벌타정(20 mg/d)치료,관찰조급여고제량신벌타정(40 mg/d)용약,연구2조적림상치료효과화용약안전성,동시평고기시치전후적혈지개선정황。결과:관찰조치료후적림상총유효솔위94.4%현저고우대조조적80.6%( P<0.05)。치료전,2조환자적총담고순、삼선감유、저밀도지단백담고순화고밀도지단백담고순등지표치상사(P>0.05),경치료후균개선,차관찰조교대조조개선경현저(P<0.05)。재치료성본상,관찰조교대조조고,차이유통계학의의( P<0.05)。결론:대노년고지혈증환자실시고제량신벌타정진행치료,수연치료성본교고,단료효경현저,대혈지수평개선효과경이상,차안전성가,치득재림상보급추엄。
OBJECTIVE:To study the feasibility of treatment of senile hyperlipidemia with different doses of simvastatin.METHODS:From May 2012 to May 2014, a total of 72 elderly patients with hyperlipidemia treated in Bethune International Peace Hospital of the Chinese People's Liberation Army were randomly divided into 2 groups. The control group was treated with small dose simvastatin butyl (20 mg/d) and the observation group with a high dose simvastatin (40 mg/d ) .The clinical efficacy and drug safety of the two groups were compared, and blood lipids improvement in two groups was evaluated.RESULTS: The overall response rate of the observation group was significantly higher than in the control group (94.4% vs.80.6%; P<0.05).Before treatment, TC, TG, LDL-C and HDL-C and other indexes of the two groups were similar ( P>0.05 ) , but after treatment, all indexes improved with better improvement showing in the observation group than in the control group ( P<0.05) .The treatment cost in the observation group was higher than in the control group (P<0.05).CONCLUSIONS:Treatment of elderly patients with hyperlipidemia using high dose simvastatin resulted in better efficacy and safety and better improvement in blood lipids in spite of its high treatment cost, which thus is worth of clinical popularization.