CAJ | 학술논문

目的：分析轻度认知障碍患者MR扩散张量成像脑白质变化及其与认知功能障碍之间的相关性。方法：选取2012年7月-2014年7月本院收治的120例轻度认知功能障碍患者作为研究对象，并依照有无深部脑白质缺血将其分为缺血组（n=78）与无缺血组（n=42），同时选取30例健康正常人作为对照组，分别对三组对象行常规磁共振与磁共振扩散张量成像检测，并采用MoCA（蒙特利尔认知）量表与MMSE（精神状态）评分量表评价纳入对象的精神状态与认知功能，观察三组对象脑白质变化与认知功能障碍之间的相关性。结果：缺血组认知功能评分为（20.29±2.00）分，明显低于未缺血组的（22.11±2.26）分，差异有统计学意义（P<0.05）；与未缺血组对比，缺血组额叶ADC值明显上升，FA值显著降低（t=4.228、3.250，P<0.05），顶叶ADC值提升，FA值明显降低（t=2.701、7.532，P<0.05）；与对照组比较，未缺血组额叶ADC升高，FA降低（t=7.791、2.874，P<0.05），海马旁回ADC提升，FA下降（t=4.414、5.163，P<0.05）。结论：在MCI患者的临床诊断中，采用MR扩散张量成像检测，可量化分析患者脑白质病变程度，确定其向阿兹海默症转化的可能性，为患者的早期治疗提供指导，值得推广。
목적：분석경도인지장애환자MR확산장량성상뇌백질변화급기여인지공능장애지간적상관성。방법：선취2012년7월-2014년7월본원수치적120례경도인지공능장애환자작위연구대상，병의조유무심부뇌백질결혈장기분위결혈조（n=78）여무결혈조（n=42），동시선취30례건강정상인작위대조조，분별대삼조대상행상규자공진여자공진확산장량성상검측，병채용MoCA（몽특리이인지）량표여MMSE（정신상태）평분량표평개납입대상적정신상태여인지공능，관찰삼조대상뇌백질변화여인지공능장애지간적상관성。결과：결혈조인지공능평분위（20.29±2.00）분，명현저우미결혈조적（22.11±2.26）분，차이유통계학의의（P<0.05）；여미결혈조대비，결혈조액협ADC치명현상승，FA치현저강저（t=4.228、3.250，P<0.05），정협ADC치제승，FA치명현강저（t=2.701、7.532，P<0.05）；여대조조비교，미결혈조액협ADC승고，FA강저（t=7.791、2.874，P<0.05），해마방회ADC제승，FA하강（t=4.414、5.163，P<0.05）。결론：재MCI환자적림상진단중，채용MR확산장량성상검측，가양화분석환자뇌백질병변정도，학정기향아자해묵증전화적가능성，위환자적조기치료제공지도，치득추엄。
Objective:To analyze the changes of cerebral white matter MR diffusion tensor imaging of brain on patients of mild cognitive impairment and the correlation with cognitive dysfunction.Method:120 patients with mild cognitive impairment admitted in our hospital from July 2012 to July 2014 were selected as the study object, in accordance with no deep white matter ischemia were divided into ischemia group (n=78) and non myocardial ischemia group (n=42), and 30 cases of healthy normal people were selected as control group, the three groups object were respectively given conventional magnetic resonance diffusion tensor imaging and detection, and using MoCA (Montreal cognitive) scale and MMSE (mental state) rating scale evaluated mental status of the object and cognitive function, and cognition of white matter changes and function correlation between barrier in brain of three groups were observed.Result:The function of ischemic group cognitive outcome score of (20.29±2.00), was significant lower than the ischemia group (22.11±2.26), the comparison between the two groups had obvious difference (P<0.05); compared with non ischemia group, ischemia group frontal ADC were increased, FA value decreased significantly (t=4.228, 3.250,P<0.05), parietal ADC value increased, FA value decreased obviously (t=2.701, 7.532,P<0.05); compared with the control group, non ischemia group frontal ADC increased, FA decreased (t=7.791, 2.874,P<0.05), parahippocampal gyrus ADC upgraded , FA decreased (t=4.414, 5.163, P < 0.05).Conclusion:In clinical diagnosis of patients with MCI, using MR diffusion tensor imaging detection can quantifiable analysis of cerebral white matter lesions level of patients, determine the possibility of conversion to Alzheimer’s disease, and provide guidance for early treatment of patients, is worthy of promotion.