CAJ | 학술논문

目的：探讨超声支气管镜引导下的经支气管镜针吸活检术（ endobronchial ultrasound－guided transbronchial needle aspiration，EBUS－TBNA）对纵隔及纵隔旁肺部病变的诊疗意义。方法收集2014年7月－2015年2月南京军区南京总医院呼吸与危重症医学科收治并接受EBUS－TBNA诊查的52例临床资料，结合患者最后诊断对EBUS－TBNA针吸活检阳性结果进行统计学分析。结果52例中通过EBUS－TBNA取得可检测标本82份，病理确诊45例，其中恶性病变33例，良性病变12例。未确诊7例中，肺硬化性血管瘤1例、肺癌4例、结核2例。敏感性为85．2％，特异性100％，准确性85．4％，阳性预测值100％，阴性预测值7．7％，所有患者无严重并发症。结论 EBUS－TBNA是对纵隔及纵隔旁肺部病变诊断的安全和微创的检查方法，而且在某些疾病诊断过程中还可进行治疗。
목적：탐토초성지기관경인도하적경지기관경침흡활검술（ endobronchial ultrasound－guided transbronchial needle aspiration，EBUS－TBNA）대종격급종격방폐부병변적진료의의。방법수집2014년7월－2015년2월남경군구남경총의원호흡여위중증의학과수치병접수EBUS－TBNA진사적52례림상자료，결합환자최후진단대EBUS－TBNA침흡활검양성결과진행통계학분석。결과52례중통과EBUS－TBNA취득가검측표본82빈，병리학진45례，기중악성병변33례，량성병변12례。미학진7례중，폐경화성혈관류1례、폐암4례、결핵2례。민감성위85．2％，특이성100％，준학성85．4％，양성예측치100％，음성예측치7．7％，소유환자무엄중병발증。결론 EBUS－TBNA시대종격급종격방폐부병변진단적안전화미창적검사방법，이차재모사질병진단과정중환가진행치료。
Objective To investigate the application value of endobronchial ultrasound guided transbronchial needle aspira-tion ( EBUS-TBNA) in the diagnosis and treatment of mediastinal and pulmonary diseases.Methods The clinical data of total 52 pa-tients who hospitalized in the department of respiratory and critical care medicine in Nanjing general hospital of Nanjing military com-mand during July 2014 to February 2015 and also taken the examination of EBUS-TBNA were obtained.The positive results of EBUS-TBNA biopsy were statistically analyzed with the final diagnosis.Results Total 82 specimens from all 52 patients were obtained via EBUS-TBNA biopsy.Among these, 45 cases were diagnosed by pathology, including 33 cases of malignant lesions and 12 cases of be-nign lesions.There were 7 patients with false-negative results, including 1 cases of pulmonary sclerosing hemangioma, 4 cases of lung cancer, 2 cases of tuberculosis.The sensitivity of EBUS-TBNA in this study was 85.2%, specificity of 100%, accuracy of 85.4%, positive predictive value of 100%, and negative predictive value of 7.7%.All patients had no serious complications.Conclusion EBUS-TBNA examination is a safe and minimally invasive method for the diagnosis of mediastinal and pulmonary diseases, which can also be used as a further therapy approach during the diagnostic process of some diseases.