中国医院用药评价与分析
中國醫院用藥評價與分析
중국의원용약평개여분석
EVALUATION AND ANAL YSIS OF DRUG-USE IN HOSPITALS OF CHINA
2015年
5期
612-614
,共3页
rhGM-CSF%莫匹罗软膏%大面积烧伤残余创面%效果%血管内皮细胞生长因子
rhGM-CSF%莫匹囉軟膏%大麵積燒傷殘餘創麵%效果%血管內皮細胞生長因子
rhGM-CSF%막필라연고%대면적소상잔여창면%효과%혈관내피세포생장인자
rhGM-CSF%Mupirocin ointment%Large residual burn wounds%Effects%Vascular endothelial growth factor
目的：探讨外用重组人粒细胞巨噬细胞集落刺激因子（ rhGM-CSF）联合莫匹罗软膏对大面积烧伤残余创面的疗效及其对血管内皮细胞生长因子的影响。方法：采用随机数字表法，将67例大面积烧伤患者（127个创面）分为观察组35例（69个创面）和对照组32例（58个创面）。观察组采用外用rhGM-CSF联合莫匹罗软膏治疗，对照组单用莫匹罗软膏治疗。对比分析2组患者的创面疗效、创面愈合率、创面平均愈合时间、创面细菌清除率及血管内皮细胞生长因子平均光密度值。结果：观察组患者总有效率（92.75％，64／69）显著高于对照组（75.86％，44／58），创面愈合率（91.30％，63／69）显著高于对照组（77.59％，45／58），创面平均愈合时间[（18.07±4.26） d]显著短于对照组[（23.18±3.72） d]，创面细菌清除率（84.62％，22／26）显著高于对照组（40.74％，11／27），治疗2周后血管内皮细胞生长因子平均光密度值（0.23±0.03）显著高于对照组（0.17±0.02），差异均有统计学意义（ P＜0.05）。结论：外用rhGM-CSF联合莫匹罗软膏对大面积烧伤残余创面的效果显著，可明显提高血管内细胞生长因子的表达，具有重要临床研究价值。
目的：探討外用重組人粒細胞巨噬細胞集落刺激因子（ rhGM-CSF）聯閤莫匹囉軟膏對大麵積燒傷殘餘創麵的療效及其對血管內皮細胞生長因子的影響。方法：採用隨機數字錶法，將67例大麵積燒傷患者（127箇創麵）分為觀察組35例（69箇創麵）和對照組32例（58箇創麵）。觀察組採用外用rhGM-CSF聯閤莫匹囉軟膏治療，對照組單用莫匹囉軟膏治療。對比分析2組患者的創麵療效、創麵愈閤率、創麵平均愈閤時間、創麵細菌清除率及血管內皮細胞生長因子平均光密度值。結果：觀察組患者總有效率（92.75％，64／69）顯著高于對照組（75.86％，44／58），創麵愈閤率（91.30％，63／69）顯著高于對照組（77.59％，45／58），創麵平均愈閤時間[（18.07±4.26） d]顯著短于對照組[（23.18±3.72） d]，創麵細菌清除率（84.62％，22／26）顯著高于對照組（40.74％，11／27），治療2週後血管內皮細胞生長因子平均光密度值（0.23±0.03）顯著高于對照組（0.17±0.02），差異均有統計學意義（ P＜0.05）。結論：外用rhGM-CSF聯閤莫匹囉軟膏對大麵積燒傷殘餘創麵的效果顯著，可明顯提高血管內細胞生長因子的錶達，具有重要臨床研究價值。
목적：탐토외용중조인립세포거서세포집락자격인자（ rhGM-CSF）연합막필라연고대대면적소상잔여창면적료효급기대혈관내피세포생장인자적영향。방법：채용수궤수자표법，장67례대면적소상환자（127개창면）분위관찰조35례（69개창면）화대조조32례（58개창면）。관찰조채용외용rhGM-CSF연합막필라연고치료，대조조단용막필라연고치료。대비분석2조환자적창면료효、창면유합솔、창면평균유합시간、창면세균청제솔급혈관내피세포생장인자평균광밀도치。결과：관찰조환자총유효솔（92.75％，64／69）현저고우대조조（75.86％，44／58），창면유합솔（91.30％，63／69）현저고우대조조（77.59％，45／58），창면평균유합시간[（18.07±4.26） d]현저단우대조조[（23.18±3.72） d]，창면세균청제솔（84.62％，22／26）현저고우대조조（40.74％，11／27），치료2주후혈관내피세포생장인자평균광밀도치（0.23±0.03）현저고우대조조（0.17±0.02），차이균유통계학의의（ P＜0.05）。결론：외용rhGM-CSF연합막필라연고대대면적소상잔여창면적효과현저，가명현제고혈관내세포생장인자적표체，구유중요림상연구개치。
OBJECTIVE:To evaluate the efficacy of rhGM-CSF plus topical mupirocin ointment for large residual burn wounds as well as its effect on vascular endothelial growth factor.METHODS:67 patients with extensive burns (127 wounds) were randomly assigend to either observation group (35 cases/69 wounds) treated with rhGM-CSF plus topical mupirocin ointment or control group(32 cases/58 wounds) treated with topical mupirocin ointment alone.The response rate, wound healing rate, average healing time, wound bacterial clearance rate and mean optical density value of vascular endothelial growth factor in the two groups were compared.RESULTS: The total response rate and the wound healing rate in the observation group were significantly higher than in the control gorup [92.75%(64/69) and 91.30%(63/69) vs.75.86%(44/58) and 77.59%(45/58)];the mean wound healing time was significantly shorter in the observation group than in the control group [(18.07 ±4.26) days vs.(23.18 ±3.72) days]; the wound bacterial clearance rate in the observation group was significantly higher than in the cotnrol group [ ( 84.62%(22/26) vs.40.74%(11/27);the mean optical density value of vascular endothelial growth factor in the observation group was significantly higher than in the cotnrol group(0.23 ±0.03 vs.0.17 ±0.02), and all the differences were statistically significant ( P <0.05 ) .CONCLUSIONS: The additional of topical rhGM-CSF to mupirocin ointment resulted in remarkable efficacy for residual burn wounds in patients with extensive burn and significantly elevated expression of vascular endothelial growth factor, which thus is of great clinical research value.
