东南国防医药
東南國防醫藥
동남국방의약
JOURNAL OF SOUTHEAST CHINA NATIONAL DEFENCE MEDICAL SCIENCE
2015年
3期
250-252
,共3页
铁缺乏%铁蛋白%心功能不全%脑钠肽前体
鐵缺乏%鐵蛋白%心功能不全%腦鈉肽前體
철결핍%철단백%심공능불전%뇌납태전체
iron deficiency%ferritin%cardiac disfunction%pro-BNP
目的：心衰患者常存在铁缺乏现象，而并非所有心衰患者都合并贫血，铁缺乏可能是影响心功能的独立危险因素。通过检测高龄心衰患者脑钠肽前体水平及血清铁蛋白和（或）转铁蛋白饱和度水平，在校正影响心功能的其他相关因素后，探讨高龄心衰患者心功能与铁缺乏的相关性。方法采集2011年1月－2013年12月因慢性心衰住院治疗的181例患者，根据血清铁蛋白水平分为铁缺乏组（105例）与铁正常组（76例）。单因素分析比较两组间脑钠肽前体水平、血红蛋白水平、肾小球率过滤、血脂、尿酸等指标，分析铁蛋白水平与脑钠肽前体的相关性。采用偏相关分析校正其他影响脑钠肽前体的因素后，分析铁蛋白水平与脑钠肽前体水平独立相关性。结果铁缺乏组患者脑钠肽前体水平[256．26±393．08）pmol／L]明显高于铁正常组[（152．28±189．90）pmol／L]，血红蛋白水平[（111．47±16．43）g／L]明显低于铁正常组[（118．87±19．51） g／L]，差异均有统计学意义（ P＜0．05）。其他指标如肾小球率过滤、尿酸、血脂等，两组组间差异无统计学意义。偏相关分析校正血红蛋白等对脑钠肽的影响，示血清铁蛋白水平和脑钠肽前体水平独立负相关（ r＝－0．160，P＝0．030）。结论高龄心功能不全患者心衰的严重程度（脑钠肽前体水平）与铁缺乏的程度（血清铁蛋白水平）呈独立负相关。
目的：心衰患者常存在鐵缺乏現象，而併非所有心衰患者都閤併貧血，鐵缺乏可能是影響心功能的獨立危險因素。通過檢測高齡心衰患者腦鈉肽前體水平及血清鐵蛋白和（或）轉鐵蛋白飽和度水平，在校正影響心功能的其他相關因素後，探討高齡心衰患者心功能與鐵缺乏的相關性。方法採集2011年1月－2013年12月因慢性心衰住院治療的181例患者，根據血清鐵蛋白水平分為鐵缺乏組（105例）與鐵正常組（76例）。單因素分析比較兩組間腦鈉肽前體水平、血紅蛋白水平、腎小毬率過濾、血脂、尿痠等指標，分析鐵蛋白水平與腦鈉肽前體的相關性。採用偏相關分析校正其他影響腦鈉肽前體的因素後，分析鐵蛋白水平與腦鈉肽前體水平獨立相關性。結果鐵缺乏組患者腦鈉肽前體水平[256．26±393．08）pmol／L]明顯高于鐵正常組[（152．28±189．90）pmol／L]，血紅蛋白水平[（111．47±16．43）g／L]明顯低于鐵正常組[（118．87±19．51） g／L]，差異均有統計學意義（ P＜0．05）。其他指標如腎小毬率過濾、尿痠、血脂等，兩組組間差異無統計學意義。偏相關分析校正血紅蛋白等對腦鈉肽的影響，示血清鐵蛋白水平和腦鈉肽前體水平獨立負相關（ r＝－0．160，P＝0．030）。結論高齡心功能不全患者心衰的嚴重程度（腦鈉肽前體水平）與鐵缺乏的程度（血清鐵蛋白水平）呈獨立負相關。
목적：심쇠환자상존재철결핍현상，이병비소유심쇠환자도합병빈혈，철결핍가능시영향심공능적독립위험인소。통과검측고령심쇠환자뇌납태전체수평급혈청철단백화（혹）전철단백포화도수평，재교정영향심공능적기타상관인소후，탐토고령심쇠환자심공능여철결핍적상관성。방법채집2011년1월－2013년12월인만성심쇠주원치료적181례환자，근거혈청철단백수평분위철결핍조（105례）여철정상조（76례）。단인소분석비교량조간뇌납태전체수평、혈홍단백수평、신소구솔과려、혈지、뇨산등지표，분석철단백수평여뇌납태전체적상관성。채용편상관분석교정기타영향뇌납태전체적인소후，분석철단백수평여뇌납태전체수평독립상관성。결과철결핍조환자뇌납태전체수평[256．26±393．08）pmol／L]명현고우철정상조[（152．28±189．90）pmol／L]，혈홍단백수평[（111．47±16．43）g／L]명현저우철정상조[（118．87±19．51） g／L]，차이균유통계학의의（ P＜0．05）。기타지표여신소구솔과려、뇨산、혈지등，량조조간차이무통계학의의。편상관분석교정혈홍단백등대뇌납태적영향，시혈청철단백수평화뇌납태전체수평독립부상관（ r＝－0．160，P＝0．030）。결론고령심공능불전환자심쇠적엄중정도（뇌납태전체수평）여철결핍적정도（혈청철단백수평）정독립부상관。
Objective Studies have confirmed that the phenomenon of iron deficiency is common in patients with heart failure and not all patients combined with anemia.Iron deficiency may be the independent risk factor of heart dysfunction.Based on the detec-tion of pro-BNP levels with elderly heart failure patients and serum ferritin and/or transferrin saturation levels, after adjustment for oth-er related influencing factors of cardiac function, to explore the correlation of cardiac function in elderly patients with iron deficiency. Methods 181 patients with chronic heart failure, hospitalized from January 2011 to December 2013, were collected according to the serum ferritin level.These patients were divided into iron deficiency group (105 cases) and normal group (76 cases).Single factor a-nalysis and comparison of two groups of pro-BNP, hemoglobin levels, rate of glomerular filtration, blood lipid, uric acid were carried out.We confirmed that ferritin level is correlated to pro-BNP.At the same time, the partial correlation analysis after correction for oth-er factors, which affect the pro-BNP, obtain that iron protein levels associated with pro-BNP levels independently.Results pro-BNP (256.26 ±393.08)pmol/L of iron deficiency group was significantly higher than that in patients in iron normal group (152.28 ± 189.90)pmol/L.The hemoglobin levels (111.47 ±16.43)g/L was lower than that in iron normal group patients (118.87 ±19.51) g/L.The difference was statistically significant (P<0.05).There was no statistically significant difference between the two groups in other indicators such as the rate of glomerular filtration, uric acid, blood lipids and so on.Using partial correlation analysis and correc-ted the hemoglobin which affect pro-BNP:serum ferritin level independently negative correlated with the level of pro-BNP (r=0.160, P=0.030).Conclusion The severity (pro-BNP) of heart failure patients in elderly is independent negatively related to the degree of iron deficiency ( serum ferritin level) .
