中国医学创新
中國醫學創新
중국의학창신
MEDICAL INNOVATION OF CHINA
2015年
15期
47-49
,共3页
心力衰竭%B型脑利钠肽%氨基末端B脑利钠肽原
心力衰竭%B型腦利鈉肽%氨基末耑B腦利鈉肽原
심력쇠갈%B형뇌리납태%안기말단B뇌리납태원
Heart failure%B-type brain natriuretic peptide%Brain natriuretic peptide amino terminal B
目的：探讨B型脑利钠肽（BNP）与氨基末端B型脑利钠肽原（NT-proBNP）在心力衰竭（以下简称心衰）患者血中的水平变化及临床意义。方法：回顾分析2013年7月1日-2014年6月30日本院心血管内科收治的82例心力衰竭患者（心衰组），采用纽约心脏病学会（NYHA）标准对心功能分级和超声心动图检查评定患者心功能，以同期住院心功能正常的患者60例作为对照组。所有患者均空腹抽取静脉血，分析2个指标（BNP、NT-proBNP）与左室射血分数（LVEF）及NYHA不同心功能级别患者之间水平的差异。结果：心衰组血BNP及NT-proBNP水平显著高于对照组，差异有统计学意义（P<0.01）。在心衰组中，随着NYHA分级增加，BNP、NT-proBNP水平逐渐升高，不同心功能级别间2个指标水平差异均有统计学意义（P<0.01）；2个指标水平与心功能分级呈明显正相关性，与LVEF分级呈负相关。结论：BNP、NT-proBNP是心衰诊断的标志物，对不同程度心衰的鉴别诊断、危险分层、指导临床治疗具有重要临床意义。
目的：探討B型腦利鈉肽（BNP）與氨基末耑B型腦利鈉肽原（NT-proBNP）在心力衰竭（以下簡稱心衰）患者血中的水平變化及臨床意義。方法：迴顧分析2013年7月1日-2014年6月30日本院心血管內科收治的82例心力衰竭患者（心衰組），採用紐約心髒病學會（NYHA）標準對心功能分級和超聲心動圖檢查評定患者心功能，以同期住院心功能正常的患者60例作為對照組。所有患者均空腹抽取靜脈血，分析2箇指標（BNP、NT-proBNP）與左室射血分數（LVEF）及NYHA不同心功能級彆患者之間水平的差異。結果：心衰組血BNP及NT-proBNP水平顯著高于對照組，差異有統計學意義（P<0.01）。在心衰組中，隨著NYHA分級增加，BNP、NT-proBNP水平逐漸升高，不同心功能級彆間2箇指標水平差異均有統計學意義（P<0.01）；2箇指標水平與心功能分級呈明顯正相關性，與LVEF分級呈負相關。結論：BNP、NT-proBNP是心衰診斷的標誌物，對不同程度心衰的鑒彆診斷、危險分層、指導臨床治療具有重要臨床意義。
목적：탐토B형뇌리납태（BNP）여안기말단B형뇌리납태원（NT-proBNP）재심력쇠갈（이하간칭심쇠）환자혈중적수평변화급림상의의。방법：회고분석2013년7월1일-2014년6월30일본원심혈관내과수치적82례심력쇠갈환자（심쇠조），채용뉴약심장병학회（NYHA）표준대심공능분급화초성심동도검사평정환자심공능，이동기주원심공능정상적환자60례작위대조조。소유환자균공복추취정맥혈，분석2개지표（BNP、NT-proBNP）여좌실사혈분수（LVEF）급NYHA불동심공능급별환자지간수평적차이。결과：심쇠조혈BNP급NT-proBNP수평현저고우대조조，차이유통계학의의（P<0.01）。재심쇠조중，수착NYHA분급증가，BNP、NT-proBNP수평축점승고，불동심공능급별간2개지표수평차이균유통계학의의（P<0.01）；2개지표수평여심공능분급정명현정상관성，여LVEF분급정부상관。결론：BNP、NT-proBNP시심쇠진단적표지물，대불동정도심쇠적감별진단、위험분층、지도림상치료구유중요림상의의。
Objective:To explore the change of blood levels and clinical significance of the b-type brain natriuretic peptide ( BNP) and the amino terminal b-type brain natriuretic peptide (NT - proBNP) in patients with heart failure (hereinafter referred to as the heart failure).Method: 82 cases of heart failure patients who were admitted in our hospital from July 2013 to June 2014 were retrospective analyzed (heart failure group). New York heart association (NYHA) standard cardiac function was used in patients with cardiac function classification and echocardiography was used to evaluate patients’ cardiac function. in the same period in the hospital, 60 cases of patients with normal cardiac function were selected as control group. All patients was drawn fasting venous blood. Two indicators,left ventricular ejection fraction (LVEF) and level of difference in patients with different cardiac function NYHA class were analyzed.Result: The blood BNP, NT - proBNP of the heart failure group were significantly higher than that of the control group, the difference was statistically significant (P<0.01). In the heart failure group, heart failure increaseed with NYHA classification, BNP, NT - proBNP level increased, the two indexes difference in different levels of cardiac function had statistical significance (P<0.01). Two index level and cardiac function classification were significantly positive correlation, negative correlation with LVEF classification.Conclusion:BNP and NT - proBNP are heart failure diagnostic markers.They have important clinical significance to the differential diagnosis,risk stratification of different degree of heart failure and the guidance of clinical.
