CAJ | 학술논문

目的：探析松弛素、盆底电生理与女性盆底功能障碍性疾病之间相关性，为疾病预防提供指导。方法：选择本院2012年5-8月收治的拟行全子宫切除术的妇科良性疾病住院患者100例进行研究，于患者术前1 d行盆底POP-Q检测、常规妇科双合诊，同时手检盆底肌力明确盆底功能、盆腔脏器脱垂情况，测定患者盆底肌力。结果：83例绝经患者所测得血清松弛素H2水平为（157.4±263.9）pg/mL，17例未绝经患者为（212.9±355.8）pg/mL，两者比较差异无统计学意义（t=0.742，P=0.460）；患者年龄（X）与血清松弛素H2水平（Y）相关性回归方程为：Y=2.987X+22.118，R2=0.006，差异无统计学意义（P>0.05），两者无显著相关性。轻度（1、2度）松弛素水平为（175.5±69.9）pg/mL，重度（3、4度）松弛素水平为（227.6±93.4）pg/mL （t=4.023，P=0.000），分度越高，血清松弛素水平越高，提示患者血清松弛素水平与盆腔器官脱垂分度存在一定相关性。患者血清松弛素H2水平与POP各径线、盆底肌力等参数之间无明显相关性。结论：松弛素及盆底电生理与盆底功能障碍性疾病之间无显著相关性，无法全面反映患者盆腔松弛程度，但与患者盆腔器官脱垂分度有一定关系，需进一步扩大样本量予以证实。
목적：탐석송이소、분저전생리여녀성분저공능장애성질병지간상관성，위질병예방제공지도。방법：선택본원2012년5-8월수치적의행전자궁절제술적부과량성질병주원환자100례진행연구，우환자술전1 d행분저POP-Q검측、상규부과쌍합진，동시수검분저기력명학분저공능、분강장기탈수정황，측정환자분저기력。결과：83례절경환자소측득혈청송이소H2수평위（157.4±263.9）pg/mL，17례미절경환자위（212.9±355.8）pg/mL，량자비교차이무통계학의의（t=0.742，P=0.460）；환자년령（X）여혈청송이소H2수평（Y）상관성회귀방정위：Y=2.987X+22.118，R2=0.006，차이무통계학의의（P>0.05），량자무현저상관성。경도（1、2도）송이소수평위（175.5±69.9）pg/mL，중도（3、4도）송이소수평위（227.6±93.4）pg/mL （t=4.023，P=0.000），분도월고，혈청송이소수평월고，제시환자혈청송이소수평여분강기관탈수분도존재일정상관성。환자혈청송이소H2수평여POP각경선、분저기력등삼수지간무명현상관성。결론：송이소급분저전생리여분저공능장애성질병지간무현저상관성，무법전면반영환자분강송이정도，단여환자분강기관탈수분도유일정관계，수진일보확대양본량여이증실。
Objective: To probe into the correlation between relaxin, pelvic floor electrical physiology and female pelvic floor dysfunction,provide guidance for disease prevention.Method: 100 patients underwent hysterectomy in benign disease in gynaecology department in our hospital from May 2012 to August 2012 were selected, detected pelvic POP-Q, conventional bimanual gynecological examination in patients the day before the operation, at the same time measured pelvic floor muscle strength to clear pelvic floor function, pelvic organ prolapse, pelvic floor muscle. Result: 83 cases of postmenopausal patients measured serum relaxin H2 level was(157.4±263.9) pg/mL, 17 cases of premenopausal patients was(212.9±355.8) pg/mL, with no significant difference (t=0.742,P=0.460).There was no significant correlation between patients age(X) and serum relaxin H2 levels(Y).The correlation regression equation: Y=2.987X+22.118,R2=0.006,had no significant difference (P>0.05), there had no significant correlation between two elements. Mild (1, 2 degree) for relaxin level (175.5±69.9) pg/mL, severe (3, 4) for relaxin level (227.6±93.4) pg/mL (comparison of two elements,t=4.023,P=0.000),the lower of the degree, the higher level of serum relaxin, suggested there was a certain correlation between serum hormone level and the degree of pelvic organ prolapse in patients. The serum H2 level had no obvious correlation with the relaxation in patients with POP and the diameters of pelvic floor muscle parameters .Conclusion:There is no significant correlation between relaxin, pelvic floor electrical physiology and pelvic floor dysfunction,so the degree of pelvic relaxation cannot be reflected completely, but they have some relationship with the degree of pelvic organ prolapse,it needs to expand the sample to confirm.