中国医学创新
中國醫學創新
중국의학창신
MEDICAL INNOVATION OF CHINA
2015年
15期
7-9
,共3页
ω-3多不饱和脂肪酸%脓毒症%免疫状态%氧化应激%影响
ω-3多不飽和脂肪痠%膿毒癥%免疫狀態%氧化應激%影響
ω-3다불포화지방산%농독증%면역상태%양화응격%영향
ω-3 polyunsaturated fatty acids%Sepsis%Immune status%Oxidative stress%Impact
目的:探究ω-3多不饱和脂肪酸对脓毒症患者氧化应激及免疫状态的影响。方法:将患者按随机数字表法分为观察组和对照组,每组各30例。两组患者均接受等氮、等热量全合一营养液肠外营养支持以及相应的常规治疗,连续7 d。其中对照组脂肪由20%中长链脂肪乳制剂提供,观察组脂肪由ω-3多不饱和脂肪酸+20%中长链脂肪乳提供。观察比较两组治疗前后氧化应激反应、免疫功能等相关指标的变化情况,并做出分析总结。结果:观察组在治疗后第8天炎症反应及免疫指标较对照组均改善明显(P<0.05),血浆脂质过氧化物LOP、血清MDA在治疗后显著下降,血清谷胱甘肽CSH上升(P<0.05),氧化应激反应得到了有效控制。结论:ω-3 PUFAs可改善脓毒症患者免疫功能,减轻炎症反应,有效控制氧化应激反应的发生。
目的:探究ω-3多不飽和脂肪痠對膿毒癥患者氧化應激及免疫狀態的影響。方法:將患者按隨機數字錶法分為觀察組和對照組,每組各30例。兩組患者均接受等氮、等熱量全閤一營養液腸外營養支持以及相應的常規治療,連續7 d。其中對照組脂肪由20%中長鏈脂肪乳製劑提供,觀察組脂肪由ω-3多不飽和脂肪痠+20%中長鏈脂肪乳提供。觀察比較兩組治療前後氧化應激反應、免疫功能等相關指標的變化情況,併做齣分析總結。結果:觀察組在治療後第8天炎癥反應及免疫指標較對照組均改善明顯(P<0.05),血漿脂質過氧化物LOP、血清MDA在治療後顯著下降,血清穀胱甘肽CSH上升(P<0.05),氧化應激反應得到瞭有效控製。結論:ω-3 PUFAs可改善膿毒癥患者免疫功能,減輕炎癥反應,有效控製氧化應激反應的髮生。
목적:탐구ω-3다불포화지방산대농독증환자양화응격급면역상태적영향。방법:장환자안수궤수자표법분위관찰조화대조조,매조각30례。량조환자균접수등담、등열량전합일영양액장외영양지지이급상응적상규치료,련속7 d。기중대조조지방유20%중장련지방유제제제공,관찰조지방유ω-3다불포화지방산+20%중장련지방유제공。관찰비교량조치료전후양화응격반응、면역공능등상관지표적변화정황,병주출분석총결。결과:관찰조재치료후제8천염증반응급면역지표교대조조균개선명현(P<0.05),혈장지질과양화물LOP、혈청MDA재치료후현저하강,혈청곡광감태CSH상승(P<0.05),양화응격반응득도료유효공제。결론:ω-3 PUFAs가개선농독증환자면역공능,감경염증반응,유효공제양화응격반응적발생。
Objective:To explore the oxidative stress and immune status impact study on sepsis patients byω-3polyunsaturated fatty acids.Method:Patients were randomly divided into observation group and control group, 30 cases in each group.Two groups of patients were accepted nutrients such as nitrogen, such as heat all-in-one parenteral nutrition support and the corresponding conventional treatment, continuous for 7 d.Which controls provided by the long chain fatty milk 20%, observation group by omega-3 polyunsaturated fatty acid + 20% long chain fatty milk.Before and after treatment oxidative stress response and immune function changes of the related indexes were compared of the two groups, and make analysis summary.Result:The observation group in the eighth day after the treatment of inflammation and immune indexes improved than the control group significantly (P<0.05), oxygen stress index, plasma lipid peroxides LOP, serum MDA declined significantly,serum glutathione GSH was increased after treatment (P<0.05), oxidative stress response to effective control.Conclusion:Omega-3 PUFAs can improve the immune function of patients with sepsis, reduce inflammation, effective control of oxidative stress reaction.